We studied kinase domain (KD) mutations, response to dose escalation, event free survival (EFS), and overall survival (OS) of 90 patients with chronic phase CML who were resistant to imatinib mesylate (IM) 400 mg. IM was escalated to 800 mg daily. There were 65 patients with hematologic ...
The A549 cells were exposed to PRI-2191 (at concentrations of 10 nM or 100 nM) and concurrently to different concentrations of imatinib and/or cytostatic drugs for 96 h. An additive effect in the proliferation inhibition of GV and PRI-2191, examined by a comparison of proliferation plots, ...
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