FAP-2286 is a cyclic peptide that binds to FAP and is currently being evaluated as a radioligand therapy to treat patients (pts) with FAP-positive solid tumors. The role of 68Ga-FAP-2286 as a diagnostic agent is unknown. We present an interim analysis of the ability of 68Ga-FAP-2286 ...
Dual-phase 99mTc-MIBI SPECT/CT in the characterization of enhancing solid renal tumors: a single-institution study of 147 cases. Clin. Nucl. Med. 45, 765–770 (2020). Article PubMed Google Scholar Parihar, A. S. et al. Diagnostic accuracy of 99mTc-sestamibi SPECT/CT for characterization...
Herein, we present a comprehensive review of FAP-targeted imaging in gastrointestinal cancers in order to clarify the current and poten- tial future role of this class of molecules in gastrointestinal oncology. Keywords Fibroblast activation protein, Cancer-associated ...
Zhu, H. et al. Dual-phase99mTc-MIBI SPECT/CT in the characterization of enhancing solid renal tumors: a single-institution study of 147 cases.Clin. Nucl. Med.45, 765–770 (2020). ArticlePubMedGoogle Scholar Parihar, A. S. et al. Diagnostic accuracy of99mTc-sestamibi SPECT/CT for charac...
Preclinical evaluation of [13xLa]La-FAP-2286 as a novel theranostic agent for tumors expressing fibroblast activation protein Article Open access 03 March 2025 Comparison of [18F]FIMP, [11C]MET, and [18F]FDG PET for early-phase assessment of radiotherapy response Article Open access 03 Febru...
Lung cancer is the leading cause of cancer-related deaths worldwide. Due to the heterogeneity of lung cancer, advances in precision medicine may enhance the disease management landscape. More recently, theranostics using the same molecule labeled with two different radionuclides for imaging and treatmen...
In this study, we present a comparative analysis of early and late PET/CT scans, using 68Ga-FAP-2286, for the detection of tumor lesions in a patient with metastatic breast adenocarcinoma.doi:10.1097/RLU.0000000000005519Banihashemian, Seyedeh Somayyeh MD...
Primary endpoint is the positive predictive value on a per-region- and per-patient-basis of 68Ga-FAPI-46 PET for detection of tumor. Key secondary endpoints were (a) association between 68Ga-FAPI-46 uptake intensity and histopathologic FAP expression, (b) accuracy of 68Ga-FAPI-46 versus ...
68Ga-FAPI-46 PET for imaging of FAP expressing cancer – a single-center prospective interventional single-arm clinical trial: study protocol and initial resultsdoi:10.1055/s-0043-1766250Fendler, W. P.Bartel, T.Pabst, K.Hirmas, N.Schaarschmidt, B....
We hypothesized that the heterodimer, recognizing both FAP and SSTR2, is advantageous over its monomeric counterpart, due to its dual receptor targeting property. Methods: FAPI-LM3 was synthesized using FAPI-46 and LM3. After radiolabeling with 68Ga (68Ga-FAPI-LM3), its FAP and SSTR2 dual...