and with the “rocks” family having a significantly lower performance than all other families, both within and across mice. Dissecting the animals’ performance, we found that, on average, mice had a high proportion of hits (Supplementary Fig.2a), as expected given that the training procedure ...
We generated transgenic animals expressing Luciferase Promoter with Myelin Basic Protein (MBP) coupled to an indicator of Firefly Luciferase.The model of Generation of bioimaging of MBP Luci provides the means to monitor the Status of myelination and the effectiveness of a test Compound Modulation of...
hypothalamic hormone-producing tumors, multiple endocrine neoplasia type 1, McCune-Albright syndrome and transgenic animals transfected with hypothalamic hormones ... S Saito,Y Yokogoshi - 《Nihon Rinsho Japanese Journal of Clinical Medicine》 被引量: 42发表: 1993年 Infantile McCune–Albright Syndrome...
Last, we demonstrated that an OPM can precisely be scaled to fit animals with varying body weight and corresponding BCAM size. The 24 g BCAM constituted the standard normal with an OPM scale factor of 1.0, whereas the OPM needed to be geometrically scaled for animals with different weights ...
The induction of adiponectin during puberty and the sexual dimorphism in adult adiponectin values were preserved in these transgenic animals. As a result of elevated adiponectin, serum PRL values and brown adipose mass both increased. The effects on carbohydrate and lipid metabolism were associated ...
"People adapted the method to study a number of interesting questions in other tissues to examine cellular relationships and cell lineages in kidney and skin cells," he said. "It was also used to examine thenervous systemin animals like zebrafish and C. elegans. With these new tools, I thin...
The lipid-lowering effects of fenofibric acid seen in clinical practice have been explained in vivo in transgenic mice and in vitro in human hepatocyte cultures by the activation of peroxisome proliferator activated receptor alpha (PPARα). Through this mechanism, fenofibrate increases lipolysis and el...
In a 24-week carcinogenicity study with racemic methylphenidate in the transgenic mouse strain p53+/-, which is sensitive to genotoxic carcinogens, there was no evidence of carcinogenicity. Male and female mice were fed diets containing the same concentrations as in the lifetime carcinogenicity study...
with an average discriminability value of d’ = 2.1 ± 0.15 (s.e.), and with the “rocks” family having a significantly lower performance than all other families, both within and across mice. Dissecting the animals’ performance, we found that, on average, mice had a high proportion...
The full potential of tagged MRI of the mouse heart for non-invasive evaluation of cardiac mechanics in transgenic animals has not been realized due toexcessive user involvement with available image processing algorithms. Therefore, we developed an automated, rapid, high-resolution analysis technique,...