A male infant with trisomy 21, born at 36weeks' gestation, had care withdrawn at 2months of age and was referred for postmortem investigations. The child had been ventilator dependent since the first week of life following surgery for intestinal perforation from necrotising enterocolitis. A CT ...
Recent reports suggest that absence or hypoplasia of the fetal nasal bone, in both the first and second trimesters of pregnancy, is a highly sensitive and specific marker of trisomy 21 [13, 14]. Microtraumas and deformities of the nose and different structures of the face skull may be a ...
whose value ranges from -1 to 1, is used to assess the goodness of a clustering. A higher silhouette coefficient means better clustering. The Calinski-Harabasz index is calculated as the ratio of the
First-trimester presentation of ultrasound findings in trisomy 13 and validation of multiparameter ultrasound-based risk calculation models to detect trisomy 13 in the late first trimester. JPME 2021, 49, 341–352. [Google Scholar] [CrossRef] Tang, J.; Han, J.; Xue, J.; Zhen, L.; Yang...