(kg•d) qd 呋塞米 Furosemide 0.5 ～ 2.0 mg/(kg• 次) qd ～ bid 氢氯噻嗪 Hydrochlorothiazide 0.5 ～ 1 mg/(kg•d) qd 螺内酯 Spironolactone 1 mg/(kg•d) qd ～ bid β 受体阻滞剂 阿替洛尔 Atenolol 0.5 ～ 1 mg/(kg•d) qd ～ bid 美托洛尔 Metoprolol 0.5 ～ 1 mg/(kg...
Dose once daily. The dosage can be increased after 1 to 2 weeks of therapy to a maximum of one 10/320 mg tablet once daily as needed to control blood pressure. The majority of the antihypertensive effect is attained within 2 weeks after initiation of therapy or a change in dose. Exforge...
Clinical Impact: Clinical studies, as well as post-marketing observations, showed that NSAIDs reduced the natriuretic effect of loop diuretics (e.g., furosemide) and thiazide diuretics in some patients. This effect has been attributed to the NSAID inhibition of renal prostaglandin synthesis. Interven...
Drug displacement studies have been performed in vitro between this highly bound drug (96%) and other drugs such as furosemide, digoxin, and warfarin. ARICEPT at concentrations of 0.3-10 micrograms/mL did not affect the binding of furosemide (5 micrograms/mL), digoxin (2 ng/mL), and warfari...