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Cardiotoxicity is an uncommon adverse effect of 5-FU treatment. Prevalence of 5- fluorouracil (FU) - induced cardiotoxicity is 2–18%, and represents an interesting clinical challenge.1 A 62 year old male was admitted to our emergency department with severe dyspnea, chest pain, diaphoresis, ...
In the treatment of early-stage CRC, MSI-H or dMMR also has good prognostic predictive value without adjuvant chemotherapy. Moreover, it plays a negative predictive role for adjuvant fluorouracil-based chemotherapy in patients undergoing curative colorectal resection76,77. Tumor mutation burden (TMB)...
In this study, a novel deep learning-based methodology was investigated to predict breast cancer response to neo-adjuvant chemotherapy (NAC) using the quantitative ultrasound (QUS) multi-parametric imaging at pre-treatment. QUS multi-parametric images of breast tumors were generated using the data ac...
associated with high and low sensitivity of drugs. Not only can it pave the way for spatial characterisation of treatment response, but it also carries the potential of ruling out treating a patient with certain drugs due to their histological profile....
Introduction: Improved survival of patients treated for Hodgkin’s disease has been increased at the cost of late complications, the most frequent of which are secondary neoplasias such as breast cancers, which account for 6–9% of these neoplasias after tr...
In the training cohort from Nanfang Hospital, 252 (49·40%) patients received 5-fluorouracil-based chemotherapy, as did 397 (51·80%) patients from Nanfang Hospital in the internal validation cohort. In the external validation cohort from Sun Yat-sen University Cancer Center, 455 (43·6%) ...
For NAC, 50% of the patients received doxorubicin (Adriamycin), cyclophosphamide followed by paclitaxel (Taxol) (AC-T), 42% received 5-fluorouracil, epirubicin, cyclophosphamide followed by docetaxel (FEC-D), 5% received doxorubicin, cyclophosphamide followed by docetaxel (Taxotere) (AC-D) and 3%...
Prospective, randomized trial of 5-fluorouracil, leucovorin, doxorubicin, and cyclophosphamide chemotherapy in combination with the interleukin-3/granulocy... We conducted a prospective randomized trial to evaluate the ability of the interleukin-3/granulocyte-macrophage colony-stimulating factor (GM-CSF) ...
Synergistic effect of celecoxib on 5-fluorouracil-induced apoptosis in hepatocellular carcinoma patients. BACKGROUND: Cyclooxygenase-2 (COX-2) enzyme over expression is reported in many human HCC cell line studies and is linked to tumor cell resistance to chemo... AR Bassiouny,A Zaky,HM Neenaa ...