Another element could be taken in consideration to explain these results: the transchelation competition of the DOTA chelator, used to link the radioisotope in 177Lu-DOTATATE, with the transferrin present in the blood perturbing the in vivo stability of 177Lu-DOTATATE [36]. What we know is ...
Introduction Patients with thalassaemia major develop iron overloading due to regularly required blood transfusions, which is treated with iron chelation therapy. To monitor the effect of this treatment the hepatic and cardiac myocardial iron content is monitored on a regular basis. Clinical management...