In contrast, within C57BL/6 mice, which fail to clear the infection, no significant accumulation of ILC2 was observed by 7 dpi, although by 14 dpi numbers appeared more comparable to infected BALB/ c mice, again consistent with previous observations31. Strikingly, in both strains of mice ...
6a)31,32. In contrast, within C57BL/6 mice, which fail to clear the infection, no significant accumulation of ILC2 was observed by 7dpi, although by 14 dpi numbers appeared more comparable to infected BALB/c mice, again consistent with previous observations31. Strikingly, in both strains ...
When wild-type (MHC-II+IL-13+) ILC2s are transferred, parasites are expelled; however, if the ILC2s lack MHC-II, the recipients fail to expel despite a vigorous Th2 response due to endogenous MHC-II+ APCs. Thus, the tables are turned and MHC interactions are required to activate (or...
PB ILCs fail to induce T-cell antigen recall responses In contrast to naive T helper cells, memory CD4+T cells might not necessarily require co-stimulation29,30. We therefore examined the possibility that ILCs could induce memory CD4+T-cell responses to the human cytomegalovirus (CMV) immune-d...