作者发现在VAT中,IL-5阳性的细胞中有一小部分是CD4+T细胞,而大多数IL-5阳性的细胞并不是T、B细胞,也不是CD11b阳性的髓系细胞,其表达CD25 (IL2Rα), IL33R (T1/ST2), CD122 (IL2Rβ), Thy1.2 (CD90.2), cKit, Sca1, and KRLG1,这与之前研究中确定的ILC2的表型一致。表达IL-13的细胞...
4C). ELISA results showed that IL-6, IL-17 A, IL-17 F, and IL-22 were significantly reduced in the blood serum and lung tissues of mice after ILC2 depletion (Fig. 4D and G). Fig. 4 ILC2 depletion inhibited Th17 cell response. A Newborn mice were treated with anti-CD90.2 ...
ARTICLES OPEN IL-4-producing ILC2s are required for the differentiation of TH2 cells following Heligmosomoides polygyrus infection VS Pelly1, Y Kannan1, SM Coomes1, LJ Entwistle1, D Ru¨ckerl2, B Seddon3, AS MacDonald4, A McKenzie5 and MS Wilson1 Immunity to many human and murine ...
M. Tuft-cell-derived IL-25 regulates an intestinal ILC2-epithelial response circuit. Nature 529, 221–225 (2016). Article CAS Google Scholar Howitt, M. R. et al. Tuft cells, taste-chemosensory cells, orchestrate parasite type 2 immunity in the gut. Science 351, 1329–1333 (2016). ...
B Background and Aims b : Tiotropium bromide (TIO) is a long-acting muscarinic antagonist, which demonstrated a high affinity of muscarinic 3 receptor (M3R). P3-3: Tiotropium bromide attenuates ILC2-derived type-2 cytokine production by suppressing IL-4 production from basoph...
68 Overexpression of IL33R in hyperactive ILC2s in response to prenatal inflammation could similarly serve as a sink for IL-33, thereby selectively regulating immune establishment and activation in the developing lung, including Tregs. These data emphasize that tissue-resident immune cells that seed ...
在过去几十年一直认为2型炎症型哮喘与由CD4+T 细胞分化的2型辅助性T 细胞（T helper type 2，Th2）密切相关，它分泌大量白介素-4（interleukin-4，IL-4）、IL-5和IL-13在内的促炎细胞因子，称这种哮喘为“Th2型哮喘”（2型炎症型哮喘），Th1/Th2细胞的失衡早已被认为是“Th2型哮喘”的发病机制[3]。
体内外研究显示,老鼠ILC2表达CysLT1R,与LTD4结合迅速激活ILC2诱导IL-4、IL-5、IL-13分泌[15]。这些结果表明,存在于人类气道过敏性炎症疾病中的CysLT和PGD2,可以强有力地激活ILC2,促进Th2细胞因子生成。在小鼠模型中发现,PGI2抑制ILC2 分泌IL-5、IL-13和减少ILC2扩散,表明PGI2可能通过抑制ILC2激活从而减弱...
Th17 and Th9 cells. ILC2-derived IL-4 promotes the TH2 differentiation. ILC2 promotes the migration of activated DC cells to mediastinal lymph nodes to activate Th2 cells to secrete IL-4, IL-5, and IL-13. Th9 can be activated by ILC2 to produce IL-9. Production of allergen-specific...
(CD200 receptor,CD200R) 是一种细为 Th2 细胞,加重 Th2 型炎症反应 [11].肥大细胞也 胞表面抑制检查点,在人和小鼠 ILC2 上均表达, 可以产生 IL-4,可能促进早期的初始 T 细胞向 Th2 并且该表达可由 IL-33 诱导,显著抑制小鼠和人类 分化 [12].此外,近年来发现 ILC2 同样在 2 型炎症 ILC2 中的...