ABX-IL8 is a humanized antibody targeting IL-8, which interferes with the tubular formation of human umbilical vein endothelial cells, inhibiting angiogenesis, tumor growth, and metastasis in human melanoma. 体外活性 ABX-IL8(100 μg/ml)不影响 A375SM 和 TXM-13 黑色素瘤细胞的增殖但下调金属蛋白...
Stress effects on FosB- and interleukin- 8(IL-8)- driven ovarian cancer growth and metastasis. J Biol Chem. 2010;285(46):35462-70.Shahzad MM, Arevalo JM, Armaiz-Pena GN, Lu C, Stone RL, Moreno-Smith M, et al. Stress effects on FosB- and interleukin-8 (IL8)-driven ovarian cancer...
Stress Effects on FosB- and Interleukin-8 (IL8)-driven Ovarian Cancer Growth and Metastasis.doi:10.1074/jbc.M110.109579growing number of studies indicate that chronic stress can accelerate tumor growth due to sustained sympathetic nervous system activation. Our recent findings suggest that chronic ...
Furthermore, it has been shown that IL8 also plays a vital role in angiogenesis which is important for tumorigenesis, progression and metastasis, and accordingly the expression levels of IL8 correlate with disease progression in several human carcinomas. Multiple N-terminal processed forms for this ...
MicroRNAs (miRNAs) have been reported to be involved in tumor metastasis. In this study, we investigated the function of miR-506 in the metastasis of human hepatocellular carcinoma (HCC). We found that miR-506 is significantly downregulated in the primary tissue of metastatic HCC and in highly...
MicroRNAs (miRNAs) have been reported to be involved in tumor metastasis. In this study, we investigated the function of miR-506 in the metastasis of human hepatocellular carcinoma (HCC). We found that miR-506 is significantly downregulated in the primary tissue of metastatic HCC and in highly...
MicroRNAs (miRNAs) have been reported to be involved in tumor metastasis. In this study, we investigated the function of miR-506 in the metastasis of human hepatocellular carcinoma (HCC). We found that miR-506 is significantly downregulated in the primary tissue of metastatic HCC and in highly...
The recombinant IL-8 antibody or scFv fragment can be formulated as pharmaceutical compositions to administer to a patient having a tumor to reduce metastasis of the tumor, reduce immune suppression in the tumor microenvironment or reduce Th2 mediated immune response.Patrick Soon-Shiong...
The recombinant IL-8 antibody or scFv fragment can be formulated as pharmaceutical compositions to administer to a patient having a tumor to reduce metastasis of the tumor, reduce immune suppression in the tumor microenvironment or reduce Th2 mediated immune response.Patrick Soon-Shiong...
MicroRNAs (miRNAs) have been reported to be involved in tumor metastasis. In this study, we investigated the function of miR-506 in the metastasis of human hepatocellular carcinoma (HCC). We found that miR-506 is significantly downregulated in the primary tissue of metastatic HCC and in highly...