[3] Kakkar, Rahul, and Richard T Lee. “The IL-33/ST2 pathway: therapeutic target and novel biomarker.” Nature reviews. Drug discovery vol. 7,10 (2008): 827-40. [4] Riera-Martínez, Lluc et al. “The Role of IL-3...
近日,宁夏医科大学总医院医学研究所科研团队在Communications Biology发表了题为Interleukin-33 promotes intrauterine adhesion formation in mice through the mitogen-activated protein kinase signaling pathway的研究论文。本文通过小鼠子宫内膜类器官模型和RNA测序技术,揭示了IL-33在IUAs形成中的作用机制,并为临床治疗IUAs...
[45] Sattler, Susanne, et al. "IL-10-producing regulatory B cells induced by IL-33 (BregIL-33) effectively attenuate mucosal inflammatory responses in the gut." Journal of autoimmunity 50 (2014): 107-122. [46] Monticelli, Laurel A.,...
在小鼠中,Il33缺乏严重减弱结肠炎和胰腺导管腺癌(PDAC)模型中炎症和LTβR激活诱导的TLSs。在PDAC中,IL-33的报警蛋白结构域激活表达LT的2组先天淋巴样细胞(ILC2s),该细胞与假定的LTβR+髓样组织细胞结合,启动三级淋巴生成。值得注意的是,淋巴源性ILC2s从肠道迁移到PDAC,可以被动员到不同组织的PDAC,并受到肠道...
interleukin-33/ST2pathogenesispulmonary fibrosisThe present study aimed to investigate the interleukin (IL)-33/ST2 pathway in a model of acute pulmonary fibrosis, and to examine the pathogenesis of pulmonary fibrosis. The pulmonary fibrosis model was established by a single exposure ...
6. T. Li, Z. J. Chen, The cGAS-cGAMP-STING pathway connects DNA damage to inflammation, senescence, and cancer. J. Exp. Med. 215, 1287–1299 (2018).7. Q. M. Anstee, H. L. Reeves, E. Kotsiliti, O. Govaere, M. Heikenwalder, From NASH to HCC: Current concepts and future ...
IL⁃33 and its signaling pathway are involved in bone me⁃ tabolism of alveolar bone in periodontitis and periapical periodontitis. The specific mechanism remains unclear, and fur⁃ ther studies are warranted. 【Key words】 IL ⁃ 33; ST2; Osteoclast; Osteoblast; Bone metabolism; ...
Under this respect, the IL-33/suppression of tumorigenesis 2 (ST2) pathway deserves consideration. Indeed, its elements are particularly expressed in the endothelium of arterial vessels, and the interaction between IL-33 and the ST2 receptor blunts the immune response characteristic of atherosclerosis....
The IL-33/ST2 pathway shapes the regulatory T cell phenotype to promote intestinal cancerThe composition of immune infiltrates strongly affects the prognosis of patients with colorectal cancer (CRC). Interleukin (IL)-33 and regulatory T cells (Tregs) in the tumor microenvironment have been ...
但当肿瘤中IL-33消失后,这种标志展示通路(flag-displaying pathway)会瓦解,癌细胞就能躲过免疫系统的“追捕”,开始扩散或转移。 该研究对数百名病人进行了调查,结果发现,前列腺癌或肾癌患者的肿瘤丢失了IL-33,五年内癌症复发更快。现在,研究人员开始调查,是否检测IL-33是监控某些类型癌症进展的有效途径。论文的第一...