2.2 STAT5调控Foxp3的表达 众多研究已经证实 IL-2可调节 Treg 功能,并调控 Foxp3的表达。而从目前的研究结果来看,STAT5蛋白的 活化对转录因子Foxp3的表达与调控起到关键作用,可能是IL-2信号调节Treg 功能的机制。早前Snow 等的研 究提示STAT5对于CD4 + CD25 + Treg 在外周维持具有重要意义,
IL18R-induced T-cell exhaustion was regulated by IL2/STAT5 and AKT/mTOR pathways, as demonstrated in an in vitro exhaustion assay. Concordantly, mice deficient in NLRP3, the molecular complex activating IL18, had decreased expression of coinhibitory receptors on intratumoral T cells and similar ...
BaF3细胞STAT5-Lu2-IL2RG-reporter基因过表达稳转株因过表达稳转株是指将目的基因整合进宿主细胞的基因组中,使该基因能在细胞内长期且稳定地过量表达,其在基因功能研究、疾病模型的构建、药物筛选、蛋白质生产以及基因 等多个领域有着广泛的应用。 构建方法 ...
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IL2RGSTAT5 phosphorylationnodular regenerative hyperplasiaSupplemental Digital Content is available in the text.Neves, Joao F.Martins, CatarinaCordeiro, Ana I.Neves, ConceicaoPlagnol, VicentCurtis, JamesFabre, MoniqueBibi, ShahnazBorrego, Luis M.Moshous, DespinaNejentsev, SergeyGilmour, Kimberly...
Novel IL2RG Mutation Causes Leaky TLOWB+NK+ SCID With Nodular Regenerative Hyperplasia and Normal IL-15 STAT5 Phosphorylation.doi:10.1097/MPH.0000000000001232Joo F NevesCatarina MartinsAna I CordeiroConceio NevesVicent PlagnolJames CurtisMonique Fabre...
15d-PGJ2 and rosiglitazone suppressed IL2-induced phophorylation of STAT5 in Vδ2 T cells.Haishan, LiC., David Pauza