在IL-2R信号通路中,STAT5蛋白的活化对转录因子 Foxp3的表达与调控起到关键作用,可能是其调节Treg的机制。 【关键词】IL-2R信号通路;JAK-STAT信号途径;STAT5蛋白;Foxp3表达;调控机制 【中图分类号】R2-03【文献标志码】A 2001年,Brunkow等对Scurfy(sf)小鼠(sf是发生在小鼠身上的进行性自身免疫缺陷病)研究时...
Here, we report the biochemical and functional characterization of a nonsense mutation in exon 8 (p.R328X) of IL2RG in two siblings: a 4-year-old boy with lethal Epstein鈥揃arr virus-related lymphoma and his asymptomatic 8-month-old brother with a TlowB+natural killer (NK)+ ...
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Novel IL2RG Mutation Causes Leaky TLOWB+NK+ SCID With Nodular Regenerative Hyperplasia and Normal IL-15 STAT5 Phosphorylation.doi:10.1097/MPH.0000000000001232Joo F NevesCatarina MartinsAna I CordeiroConceio NevesVicent PlagnolJames CurtisMonique Fabre...
IL2RGSTAT5 phosphorylationnodular regenerative hyperplasiaSupplemental Digital Content is available in the text.Neves, Joao F.Martins, CatarinaCordeiro, Ana I.Neves, ConceicaoPlagnol, VicentCurtis, JamesFabre, MoniqueBibi, ShahnazBorrego, Luis M.Moshous, DespinaNejentsev, SergeyGilmour, Kimberly...
15d-PGJ2 and rosiglitazone suppressed IL2-induced phophorylation of STAT5 in Vδ2 T cells.Haishan, LiC., David Pauza
PPARγ Promotes Mannose Receptor Gene Expression in Murine Macrophages and Contributes to the Induction of This Receptor by IL-13 that MMR induction by IL-13 via PPARγ is dependent on phopholipase A2 activation and that IL-13 induces 15d-PGJ2 production and nuclear localization. ... A Coste...