IL-1 beta and IL-6 selectively induce transforming growth factor-beta isoforms in human articular chondrocytes. J Immunol 1993;151:3337-44.Villiger, PM, Kusari AB, ten Dijke P, and Lotz M (1993) IL-1 beta and IL
IL-1, IL-6, TNF-and TGF-mRNA expression were same as observed in immunoreactivity for each cytokines. Conclusion: When monocytes are stimulated with LPS under serum-free conditions, IL-6 and TNF-are secreted in early stage of inflammation. In contrast, the secretion of TGF-arise in the ...
在HT-29 / MTX细胞中IL-1β刺激后,TNF受体相关因子6转染后,kappaB-萤光素酶报告基因的活性提高了16倍。我们得出的结论是,HT-29细胞的细胞分化选择性损害了IL-1beta信号通路,从而抑制了NF-kappaB和JNK响应IL-1beta的活性。对IL-1β的这种相对无反应性可能代表了分化的肠上皮细胞的重要调节机制。
摘要: METHODS: Male and female Wistar rats (weight range, 130-180 g) from our breeding facilities were used. Both genders were used based on our observation that formalin injection produces the same pattern of flinching in either sex (unpublished observation)....
646: Exposure to interleukin-1 beta (IL-1β) induces changes in progesterone receptor (PR)-A and -B expression in human cervical fibroblasts (HCFs)A 21-month-old boy presented with a papular rash, lymphoadenopathy, and splenomegaly. He developed symmetric polyarthritis, fever, and progressive ...
its effect on RAW 264.7 macrophage morphology alteration, phagocytic activity change, and interleukin (IL) 6 and IL-17A production was examined. Moreover, the treated RAW 264.7 macrophages were analysed to predict signal transduction through next-generation sequencing (NGS) and the related gene expres...
The protein levels of MCP-1 and RANTES with stimulation of 1.0ng/mL of IL-1beta for 24 hours were higher than those without(30.0+/-2.22 vs 3.55+/-0.74ng/105cells and 1.53+/-0.41 vs 0.11+/-0.02ng/105cells respectively, p<0.05, n=6). Chemotaxis assay showed that the supernatants ...
New 5,6-bis(4-methoxyphenyl)-2H-pyridazin-3-one derivatives were prepared, and their abilities to inhibit IL-1β production were evaluated. Some compounds showed potent inhibitory activity against IL-1β production in HL-60 cells stimulated with lipopolysaccharide (LPS). The synthesis and structure...
21. Compared to the PBS group (negative control group, PBS was used as a control, the actual value was 0), 18H11-Hu-C53A had an inhibitory rate of as high as 91.06% on IL-6 secretion in mice when used at a dose of 2.5 mg/kg, an inhibitory rate of 73.11% on IL-6 secretion ...
Interleukin-6 (IL-6)-type cytokines are pleiotropic molecules capable of stimulating bone resorption and expressed by numerous cell types. In the present study, we tested the hypothesis that gingival fibroblasts may ...