20.细胞因子IL-17C通过与膜表面受体IL-17RE结合,促进TH17细胞活化。多种自身免疫性疾病与TH17细胞的过度活化有关。某研究小组制备特异性识别人IL-17C的单克隆抗体并进行功能鉴定。实验时取4只周龄相同的小鼠,每隔20天共进行4次对小鼠皮下注射等量人L-170蛋白,并进一步制备单克隆抗体。下列有关说法错误的是 A.自...
虽然TH17细胞是真菌感染中IL-17的主要来源,但NK细胞和ILCs也是真菌感染免疫中IL-17A和IL-17F的重要来源。IL-17还可以调节保护性TH1细胞反应并增强真菌感染的免疫病理学。在致密隐球菌感染的小鼠模型中,γδT细胞早期分泌IL-17抑制了真菌清除所需的保护性TH1细胞反应,并促进中性粒细胞相关炎症。
概述:IL-17RE 是 IL-17C 的特异性功能受体,主要由上皮细胞和淋巴细胞表达,如 Th17 细胞[1]。IL-17C/IL-17RE 轴在许多炎症和免疫疾病中发挥作用[2]。此外,在 IL-17RE 和任何其他 IL-17 细胞因子家族成员之间未发现相互作用。IL-17C 通过 IL-17RE-IL-17RA 复合物激活下游信号传导,以诱导编码抗菌肽和促...
本研究选取白细胞介素-17C(IL-17C)作为靶标,这是IL-17细胞因子家族中的一个独特成员,它可以特异性地与上皮细胞和TH17细胞上表达的白细胞介素-17受体E(IL-17RE)结合,并通过一个异源二聚体受体复合物IL-17RA/RE进行信号传导,诱导自身免疫、炎症、宿主防御等信号通路。阻断IL-17C和IL-17RE的相互作用,为治疗...
N‑terminal deletions or deletion/substitution of the transmembrane segment (3). IL‑17 RE is expressed on keratinocytes, mucosal epithelial cells, Th17 cells, and gamma /δ T cells (4, 5). It associates with the widely expressed IL‑17 RA to form a heterodimeric receptor for IL-17C ...
mucosal epithelial cells, Th17 cells, and gamma /δ T cells (4, 5). It associates with the widely expressed IL-17 RA to form a heterodimeric receptor for IL-17C (4-6). IL-17C binds to IL-17 RE with high affinity and to IL-17 RA with low affinity (4, 5). IL-17C expression ...
IL-17 and Th17 Cells. Annu. Rev. Immunol. 27, 485–517 (2009). Article CAS Google Scholar Ivanov, I.I. et al. Specific microbiota direct the differentiation of IL-17-producing T-helper cells in the mucosa of the small intestine. Cell Host Microbe 4, 337–349 (2008). Article CAS ...
IL‑17C is additionally up‑regulated in Th17 cell dependent autoimmunity (5). In this setting, it exacerbates disease severity by inducing Th17 cell production of IL‑17A, IL‑17F, IL‑22, CCR6, and CCL20 (5). The up‑regulation of IL‑17 RE in hepatocellular carcinoma is ...
IL-17RE expression, on the other hand, was not only found in Th17 cells but also in regulatory T cells isolated from colon and small intestine. Therefore, we adopted a CD4 transfer colitis model, where Il17re deficient CD45RBhi CD4+ cells or Il17re deficient CD25+CD4+ cells were ...
The importance of the IL-17R pathway has been observed not only in knockout mouse models, but also in humans with rare genetic mutations that impact generation of Th17 cells or the IL-17 signaling pathway, including Hyper-IgE Syndrome (STAT3 or TYK2 mutations) or IL17RA or ACT1 gene ...