来源:Mammalian cell 分子量:45.5 kDa 表达区域:33-205aa 蛋白标签:C-terminal hFc-tagged 产品提供形式:Liquid or Lyophilized powder 功能:白细胞介素-15高亲和力受体。可以在顺式和反式两种方式发出信号,其中一个细胞亚群的IL15R向邻近表达il2rg的细胞表达IL15。在中性粒细胞中,结合并激活激酶SYK以响应...
背景说明: 小鼠白细胞介素-15受体亚单位α,又称IL15ra,是白介素-15的高亲和力受体。IL15ra以异三聚体的形式与IL-2受体β和γ亚基(公共γ链或γc)结合,启动信号转导。它可以在顺式和反式中信号,其中IL15R从一个细胞的子集呈现IL 15到邻近的IL2RG表达细胞。IL15ra在特殊细胞中表达,包括多种tand B细胞和...
specific T cells for therapeutic administration to a human patient having or suspected of having a pathogen or cancer, utilizing soluble IL-15/IL-15R伪 complexes ex vivo, in cell culture during ex vivo sensitizing of T cells to the antigen or during ex vivo culturing of antigen-specific T ...
二、利用plenti载体质粒及辅助质粒转导293t细胞以包装慢病毒,并将包装出的慢病毒转染jurkatcell以计算病毒滴度 (1)在15cm细胞皿中培养293t细胞,等待293t细胞长满至全视野70%时,用1.5mlpbs重悬60ugpei,1.5mlpbs重悬总质量为20ug的plenti载体质粒及辅助质粒; (2)室温静置5min,将pbs-pei混合液加至pbs-dna混合液中...
IL-15RA Antibody: Interleukin 15 (IL-15RA) is a cytokine receptor that specifically binds IL-15 with high affinity. IL-15 regulates T and natural killer cell activation and proliferation. The IL-15 and IL-2 receptors share two subunits, IL-2R beta and IL-2R gamma, and IL-15RA is ...
所述的CCL21趋化因子由SEQ ID NO.5 所示的核苷酸序列编码得到,IL15RA‑IL15融合蛋白和CCL21由2A自剪切肽连接, 该2A自剪切肽由SEQ ID NO.4所示的核苷酸序列编码; 所述IL15RA‑IL15能够促进T、 NK、 NKT细胞的活化和增殖, CCL‑21可以募集外周CCR7阳性的初始T细胞、 记忆T细胞、和树突状细胞进入淋巴组织...
描述: IL-15 and IL-15 receptor alpha (IL-15Rα) play a significant role in multiple aspects of T cell biology. Interleukin (IL)-15 is essential for natural killer (NK), NKT and memory (m) CD8+ T cell development and function, and is currently under investigation as an immunotherapeutic...
(PMID: 7641685). The IL-15Rα chain is expressed by many cell types including monocytes, DCs, NK, T cells and fibroblasts. Several isoforms of IL-15Rα exist and are generated either by alternative splicing or by proteolytic cleavage (PMID: 10480910; 15265897). The calculated molecular weight...
Interleukin 15 (IL-15RA) is a cytokine receptor that specifically binds IL-15 with high affinity. IL-15 regulates T and natural killer cell activation and proliferation. The IL-15 and IL-2 receptors share two subunits, IL-2R beta and IL-2R gamma, and IL-15RA is structura...
Interleukin 15 (IL-15RA) is a cytokine receptor that specifically binds IL-15 with high affinity. IL-15 regulates T and natural killer cell activation and proliferation. The IL-15 and IL-2 receptors share two subunits, IL-2R beta and IL-2R gamma, and IL-15RA is struct...