IL-15 AND IL-15R ALPHA SUSHI DOMAIN BASED IMMUNOCYTOKINESMORISSEAU SBASTIEN DANIELTEPPAZ GRALDINEJACQUES YANNICK LAURENT JOSEPHROBERT BRUNO GILBERT MARCDE MARTYNOFF GUY LUC MICHELBECHARD DAVID
US20090238791 2006年10月6日 2009年9月24日 Institut National De La Sante Et De La Recherche Medicale Il-15ralpha sushi domain as a selective and potent enhancer of il-15 action through il-15beta/gamma, and hyperagonist (il-15ralpha sushi - il-15) fusion proteins...
linked by covalence to said conjugate, wherein said conjugate comprises (i) a polypeptide comprising the amino acid sequence of the interleukin 15 or derivatives thereof, and a polypeptide comprising the amino acid sequence of the sushi domain of the IL-15R± or derivatives thereof; and uses ...
(2) antibody or its segment, which passes through, to be directly or indirectly covalently attached and the conjugate, the IL-15R 伪 or derivative of sushi structural domain of the conjugate including (I) polypeptide comprising amino acid sequence interleukin 15 or its derivative and polypeptide ...
linked by covalence to said conjugate, wherein said conjugate comprises (i) a polypeptide comprising the amino acid sequence of the interleukin 15 or derivatives thereof, and a polypeptide comprising the amino acid sequence of the sushi domain of the IL-15R卤 or derivatives thereof; and uses ...
linked by covalence to said conjugate, wherein said conjugate comprises (i) a polypeptide comprising the amino acid sequence of the interleukin 15 or derivatives thereof, and a polypeptide comprising the amino acid sequence of the sushi domain of the IL-15R卤 or derivatives thereof; and uses ...
linked by covalence to said conjugate, wherein said conjugate comprises (i) a polypeptide comprising the amino acid sequence of the interleukin 15 or derivatives thereof, and a polypeptide comprising the amino acid sequence of the sushi domain of the IL-15R伪 or derivatives thereof; and uses ...
Suitable compounds, the IL-15R beta / gamma at least one coupling element which is attached directly or indirectly by covalence to at least one polypeptide containing the sushi domain of the extracellular region of IL-15R alpha It includes compounds containing.ジャック,ヤニック...
Appropriate compounds include compounds comprising at least one IL-15Rbeta/gamma binding entity, directly or indirectly linked by covalence to at least one polypeptide which contains the sushi domain of the extracellular region of an IL-15Ralpha.ジャック,ヤニック...
Suitable compounds, the IL-15R beta / gamma at least one coupling element which is attached directly or indirectly by covalence to at least one polypeptide containing the sushi domain of the extracellular region of IL-15R alpha It includes compounds containing.ジャック,ヤニック...