ArticlePubMedGoogle Scholar Shoham, N. G.et al. Pyrin binds the PSTPIP1/CD2BP1 protein, defining familial Mediterranean fever and PAPA syndrome as disorders in the same pathway.Proc. Natl Acad. Sci. USA100, 13501–13506 (2003). ArticleCASPubMedPubMed CentralGoogle Scholar Yu, J. W.et al...
Almost without exception, normal T cells or their progeny require accessory cells (AC) or their products for activation and proliferation induced by mitogens, antigens and soluble anti-idiotypic antibodies. Despite many years of effort, the role of MHC products, interleukin-1 (IL-1) and other...
[3] Weber A, Wasiliew P, Kracht M. Interleukin-1 (IL-1) pathway[J].Science signaling, 2010, 3(105): cm1-cm1. [4] Weiterer S S, Meier‐Soelch J, Georgomanolis T, et al. Distinct IL‐1α‐responsive enhancers promote acute and coordinated changes in chromatin topology in a hierar...
Thus, the IL-1 pathway plays a key role in triggering RNA vaccine-associated innate signaling, an effect that was unexpectedly amplified by certain lipids used in vaccine formulations incorporating N1-methyl-pseudouridine-modified RNA to reduce activation of Toll-like receptor signaling. This is a ...
IL-1家族细胞因子通过与受体亚基结合激活细胞内信号通路,如IL-1RI/IL-1R1、IL-18Rα/IL-1R5、IL-1Rrp2/IL-1R6或ST2/IL-1R4,然后募集一个辅助受体来形成活性受体复合物。由IL-1α、IL-1β、IL-18、IL-33、IL-36α、IL-36β或IL-36γ触发的信号级联激活MAPK和NF-κB,导致促炎因子、趋化因子和炎症...
Interleukin-1 (IL-1) PathwayMechanisms of interleukin-1b releaseThe role of interleukin-1 in general pathologyThe TLR and IL-1 signalling network at a glanceA clinical perspective of IL-1b as the gatekeeper of inflammationOverview of the IL-1 family in innate inflammation and acquired immunity...
1. Introduction: The IL-33/IL-1RL1 pathway as a central nexus in asthma 2. The IL-33/IL-1RL1 pathway in asthma 3. Genetics of the IL-33/IL-1RL1 pathway 4. Towards precision medicine 5. Conclusion Declaration of Competing Interest Acknowledgements ReferencesShow full outline Cited by (82...
IL-1β mediated up-regulation of HIF-1α via an NFkB/COX-2 pathway identifies HIF-1 as a critical link between inflammation and oncogenesis tumorigenesis, we investigated whether the HIF-1 signaling pathway was stimulated by the pro-inflammatory cytokine interleukin-1beta (IL-1beta) in A549 ...
Kraft, L., Erdenesukh, T., Sauter, M.et al.Blocking the IL-1β signalling pathway prevents chronic viral myocarditis and cardiac remodeling.Basic Res Cardiol114, 11 (2019). https://doi.org/10.1007/s00395-019-0719-0 Download citation ...
IL-1β promotes transendothelial migration of PBMCs by upregulation of the FN/α5β1 signalling pathway in immortalised human brain m... Neuroinflammation is often associated with pathological changes in the function of the blood-brain barrier (BBB) caused by disassembly of tight and adheren......