IL1RN基因编码的产物IL-1Ra,是一种内源性的IL-1受体拮抗剂。当身体遭受外来刺激时,IL-1Ra就会迅速上调表达,与IL-1β竞争性结合IL-1受体,从而阻断IL-1β的下游效应,遏制炎症反应的过度扩散。可以说,IL-1Ra就是调控"细胞因子风暴"的"保护伞"。研究发现,携带IL1RN基因"有利"基因型的患者,不仅体内IL-1β含量...
[15]Li C, Tan X, Zhang J, et al. Gene mutations and clinical phenotypes in 15 Chinese children with cryopyrin-associated periodic syndrome (CAPS)[J]. Sci China Life Sci, 2017, 60: 1436-1444. [16]Livneh A, Dr...
A complementary DNA (cDNA) probe for the predominant (pI 7) form of human monocyte-derived interleukin-1 (IL1) and a collection of 30 human-mouse somatic cell hybrids were used to assign the IL1 gene to human chromosome 2 by Southern blot analysis of hybrid cell DNA digested with the ...
2.6IL1 gene IL-1 cytokines (IL-1A, IL-1B and IL-1RA) are key factors in immune regulation and inflammatory processes[44]. Genes coding for these molecules are located close to each other on chromosome 2q13-14 and have several common polymorphisms. IL1A has two variants, both are C to...
(2)通过分析1b期接受了RNA-LPX(autogene cevumeran,基于BioNTech的iNeST癌症疫苗技术平台生成的个体化新抗原疫苗。)的9名癌症患者的治疗前和治疗后血浆IL-1β水平。 (3)通过确定人PBMC释放的IL-1α、IL-1β和IL-1ra的量来研究IL-1ra是否在调节R...
NCT05604560:A Neoadjuvant Study of Tislelizumab and SX-682 for Resectable Pancreas Cancer (BeiGene和Syntrix Biosystems, Inc.) 小结 促肿瘤炎症是癌症的标志之一,这种炎症由细胞因子(如IL-1β、TNFα和IL-6)来维持。肿瘤内髓系抑制细胞大量产生这些细胞因子,通常与实体瘤的不良预后相关。TNFα和IL-1β与...
Interleukin-1 is a pro-inflammatory cytokine with multiple biological effects. The IL-1 gene family encodes three proteins: IL-1α, IL-1β and their naturally occurring inhibitor Il-1RN. Interleukin 1β(IL-1β), mainly produced by blood monocytes and tissue macrophages, has been implicated in...
Genome-wide association analysis and CRISPR–Cas9 genome editing identified rs1921622, a genetic variant in an enhancer element of IL1RL1, which downregulates gene and protein levels of sST2. Mendelian randomization analysis using genetic variants, including rs1921622, demonstrated that decreased sST2 ...
基因序列:NCBI_Gene:17082 蛋白序列: UniprotKB:P14719 UniprotKB:G3UYU3 UniprotKB:Q3UM53 UniprotKB:Q5D095 小鼠Mouse Il1rl1 靶点分子功能(预测) Enables interleukin-33 binding activity and interleukin-33 receptor activity. Involved in several processes, including negative regulation of T-helper 1 type ...
(IL1B), and modulates a variety of interleukin 1 related immune and inflammatory responses. This gene and five other closely related cytokine genes form a gene cluster spanning approximately 400 kb on chromosome 2. A polymorphism of this gene is reported to be associated with increased risk of...