[15]Li C, Tan X, Zhang J, et al. Gene mutations and clinical phenotypes in 15 Chinese children with cryopyrin-associated periodic syndrome (CAPS)[J]. Sci China Life Sci, 2017, 60: 1436-1444. [16]Livneh A, Dr...
doi:10.1016/0165-5728(94)90534-7D.S.SkundricandB.BealmearandR.P.LisakJournal of NeuroimmunologySkundric DS, Bealmear B, Lisak RP. (1994) IL-1 gene expression in cultured rat Schwann cells (SC).' J Neuroimmunol54: 190.
IL1RN基因编码的产物IL-1Ra,是一种内源性的IL-1受体拮抗剂。当身体遭受外来刺激时,IL-1Ra就会迅速上调表达,与IL-1β竞争性结合IL-1受体,从而阻断IL-1β的下游效应,遏制炎症反应的过度扩散。可以说,IL-1Ra就是调控"细胞因子风暴"的"保护伞"。研究发现,携带IL1RN基因"有利"基因型的患者,不仅体内IL-1β含量...
2.6IL1 gene IL-1 cytokines (IL-1A, IL-1B and IL-1RA) are key factors in immune regulation and inflammatory processes[44]. Genes coding for these molecules are located close to each other on chromosome 2q13-14 and have several common polymorphisms. IL1A has two variants, both are C to...
NCT05604560:A Neoadjuvant Study of Tislelizumab and SX-682 for Resectable Pancreas Cancer (BeiGene和Syntrix Biosystems, Inc.) 小结 促肿瘤炎症是癌症的标志之一,这种炎症由细胞因子(如IL-1β、TNFα和IL-6)来维持。肿瘤内髓系抑制细胞大量产生这些细胞因子,通常与实体瘤的不良预后相关。TNFα和IL-1β与...
3. Armingol E, Officer A, Harismendy O, Lewis NE. Deciphering cell-cell interactions and communication from gene expression.Nat Rev Genet2021;22(2):71-88 doi10.1038/s41576-020-00292-x. 4. Fiscon G, Paci P. SAv...
AIM: To investigate the effect of IL-1 gene polymorphism on the expression of IL-1β mRNA in patients with rheumatoid arthritis. METHODS: The method of FQ-RT-PCR was used to detect the expression of IL-1β mRNA in peripheral blood mononuclear cells separated from rheumatoid arthritis patients...
Genome-wide association analysis and CRISPR–Cas9 genome editing identified rs1921622, a genetic variant in an enhancer element of IL1RL1, which downregulates gene and protein levels of sST2. Mendelian randomization analysis using genetic variants, including rs1921622, demonstrated that decreased sST2 ...
基因序列:NCBI_Gene:17082 蛋白序列: UniprotKB:P14719 UniprotKB:G3UYU3 UniprotKB:Q3UM53 UniprotKB:Q5D095 小鼠Mouse Il1rl1 靶点分子功能(预测) Enables interleukin-33 binding activity and interleukin-33 receptor activity. Involved in several processes, including negative regulation of T-helper 1 type ...
Entrez Gene ID:(Mouse) 54448 功能 cytokine activityinterleukin-1 receptor bindinginterleukin superfamily 参与通路 positive regulation of cytokine productionimmune system processinflammatory responseimmune responsecytokine-mediated signaling pathwaypositive regulation of interleukin-6 productioninnate immune response...