急性肺损伤(ALI)/急性呼吸窘迫综合征(ARDS)是由多种效应细胞,炎性介质共同参与,并呈现出级联放大的继发性弥漫性肺实质损伤和瀑布样炎症继发性损伤.据统计[1],ALI/ARDS的病死率在26%~35%,其致病环节众多,发病机制复杂,病因多元化,已成为临床危重病学研究的难点和热点问题.近年来,IL-6/GP130/STAT3信号通路靶向...
Claudin-3 loss also upregulated the gp130/IL6/Stat3 signaling in colonic epithelium potentially assisted by infiltrating immune components. Genetic and pharmacological studies confirmed that claudin-3 loss induces Wnt/β-catenin activation, which is further exacerbated by Stat-3-activation and help ...
Mesenchymal stem cells isolated from human gliomas increase proliferation and maintain stemness of glioma stem cells through the IL-6/gp130/STAT3 Pathway. ... A Hossain,J Gumin,F Gao,... - 《Stem Cells》 被引量: 53发表: 2015年 Mesenchymal Stem Cells Isolated From Human Gliomas Increase Pr...
Earlier, using athymic nude mice, we illustrated that capsaicin inhibits human MM tumor growth by inhibition of STAT3 signaling pathway [239]. Studies from independent group reported that in glial tumor capsaicin depletes intracellular gp130 pools and thus inhibits IL-6 induced STAT3 signaling pathway...