据优卡迪生物资料介绍,ssCART-19是其开发的第四代CAR-T产品,可同时表达CAR结构和IL-6沉默元件,可显著降低IL-6因子的释放水平,从而进一步降低单核细胞活化和促炎细胞因子的释放,从预防层面来减轻严重细胞因子释放综合征(CRS)和严重免疫效应细胞相关神经毒性综合征(ICANS)的发生率,从而提高CAR-T的用药
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Notably, a single dose of IL-5-anchored CCAR-T cells resulted in persistent protection against asthma-related conditions over three months, significantly exceeding the typical therapeutic window of current mAb-based treatments in the clinics. This study presents a cell-based treatment strategy for ...
细胞因子分析显示M2组IL-1ra升高,而IL-1β、GRO等促炎因子降低。 IL-1ra中和抗体增强CAR-T19抗肿瘤活性 IL-1β可促进CAR-T增殖,而IL-1ra或M2条件培养基逆转该效应。小鼠模型中,IL-1ra中和抗体联合CAR-T19显著延缓肿瘤生长,生存期延长。 IL-1ra通过IL-1RI抑制CAR-T19功能 激活的CAR-T19高表达IL-1受体I(IL...
4.传奇生物CAR-T骨髓瘤长期疗效见刊。传奇生物BMCA CAR-T疗法西达基奥仑赛(Carvykti)在《Targeted Oncology》期刊上公布用于治疗中国复发或难治性多发性骨髓瘤(r/r MM)的Ib/II期CARTITUDE-1试验(NCT03548207)最新积极结果。在中位随访为27.7个月时,ORR为97.9%,sCR率为82.5%,非常好的部分缓解率为12.4%,PR率为...
了证实该CAR-T的优异的性能表现是因为IL-7和CCL19的影响,该团队使用了抗CD127抗体来抑制细胞上IL-7的受体,从而降低IL-7的作用。使用抗CCR-19的抗体来抑制CCL19的受体降低CCL19的作用。7 × 19 CAR-T细胞的强增殖能力被抗CD127抗体削...
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Matrix metalloproteinase (MMP), a class of zinc- dependent proteinases, has important function in tissue remodeling, wound healing and cardiovascular diseases through regulated degradation of the ECM and facilitat- ing extracellular matrix [18, 19]. Degradation of ECM is required for cell migration ...
Interleukin-5 (IL-5) is one of the important members of the interleukin family, also known as T cell replacing factor (TRF), B cell growth factor-II (BCGF-II), IgA-enhancing factor (IgA-EF), or eosinophil differentiation factor (EDF). It is a homodimeric glycoprotein secreted mainly by...
Interleukin-5 (IL-5) is one of the important members of interleukin family, also known as T cell replacing factor (TRF), B cell growth factor-II (BCGF-II), IgA-enhancing factor (IgA-EF), or eosinophil differentiation factor (EDF) which is a homo-dimeric glycoprotein secreted mainly by ...