Accordingly, the expression level of the IL-4 gene in asthmatic mice and asthmatic mice treated with vitamin D was 0.6 and 0.2, respectively, while the expression level of the IL-10 in these groups was 1.2 and 2.8, respectively, which showed significant changes (p-value < 0.05) in ...
IL-4 is the primary cytokine implicated in the development of Th2-mediated responses, which is associated with allergy and asthma. The Type I receptor comprises IL-4Rα and the common gamma-chain (γc), which is also shared by the cytokines IL-2, -7, -9, -15 and -21 and is pres...
The role of the mast cell in asthma: a reassessment. Curr. Opin. Allergy Clin. Immunol. 3, 45–50 (2003). CAS PubMed Google Scholar Zheng, W. & Flavell, R. A. The transcription factor GATA-3 is necessary and sufficient for TH2 cytokine gene expression in CD4 T cells. Cell 89,...
4. Imani Danyal,Eslami Mohammad Masoud,AnaniSarab Gholamreza,Aliyu Mansur,Razi Bahman,Rezaei Ramazan. Interleukin-4 gene polymorphism (C33T) and the risk of the asthma: a meta-analysis based on 24 publications. BMC Med Genet. 2020;21(1):232.产品...
IL-8inthreegroupsweremeasuredbyradioimmunoassay.Results:①ThelevelsofIL-4、IL-8inshangqingyezhoofasthmagroupwerehigherthanthatofhealthygroup(P<0.01).②ThelevelsofIL-4、IL-8fromPBMCofcontrolgroupwerehigherthanthatofnornalgroup(P<0.01).③ThelevelofIL-4andIL-8inPBMCofVIPgroupwaslowerthanthatofcontrol...
Here we used single-cell RNA sequencing of human and mouse non-small cell lung cancer (NSCLC) lesions, and found that in both species the type 2 cytokine interleukin-4 (IL-4) was predicted to be the primary driver of the tumour-infiltrating monocyte-derived macrophage phenotype. Using a ...
and HIV infections. IL-4 is firstly identified as a T cell-derived growth factor for B cells. IL-4 can mediate important pro-inflammatory functions in asthma, including T helper cell type 2 lymphocyte differentiation, induction of IgE production, up-regulation of IgE receptors, expression of va...
and placenta. Used to study Sjogren's syndrome; atopic dermatitis; and type 1 diabetes mellitus. Human ortholog(s) of this gene implicated in several diseases, including asthma (multiple); autoimmune disease (multiple); hepatitis B; hepatitis C; and pancreatic cancer (multiple). Orthologous to ...
IL4RA gene expression in relation to I50V, Q551R and C-3223T polymorphisms. Danielewicz, Dębińska, Drabik-Chamerska, Kalita, Boznański, Adv Clin Exp Med(2021 Jan) Intranasal IL-4 Administration Alleviates Functional Deficits of Periventricular Leukomalacia in Neonatal Mice. Yu, Miao, Li...
Human ortholog(s) of this gene implicated in several diseases, including asthma (multiple); autoimmune disease (multiple); hepatitis B; hepatitis C; and pancreatic cancer (multiple). Orthologous to human IL4 (interleukin 4). [provided by Alliance of Genome Resources, Apr 2022] Amplicon ...