Accordingly, the expression level of the IL-4 gene in asthmatic mice and asthmatic mice treated with vitamin D was 0.6 and 0.2, respectively, while the expression level of the IL-10 in these groups was 1.2 and
Asthma, rhinitis and hayfever are atopic disorders characterized by high serum levels of immunoglobulin E and skin sensitization to common environmental allergens. About this article Cite this article Li-Weber, M., Krammer, P. Regulation ofIL4gene expression by T cells and therapeutic perspectives....
IL-4 is the primary cytokine implicated in the development of Th2-mediated responses, which is associated with allergy and asthma. The Type I receptor comprises IL-4Rα and the common gamma-chain (γc), which is also shared by the cytokines IL-2, -7, -9, -15 and -21 and is pres...
4. Imani Danyal,Eslami Mohammad Masoud,AnaniSarab Gholamreza,Aliyu Mansur,Razi Bahman,Rezaei Ramazan. Interleukin-4 gene polymorphism (C33T) and the risk of the asthma: a meta-analysis based on 24 publications. BMC Med Genet. 2020;21(1):232.产品...
IL-8inthreegroupsweremeasuredbyradioimmunoassay.Results:①ThelevelsofIL-4、IL-8inshangqingyezhoofasthmagroupwerehigherthanthatofhealthygroup(P<0.01).②ThelevelsofIL-4、IL-8fromPBMCofcontrolgroupwerehigherthanthatofnornalgroup(P<0.01).③ThelevelofIL-4andIL-8inPBMCofVIPgroupwaslowerthanthatofcontrol...
IL-4 signals enhance growth, survival, FceRI levels, and anti-apoptotic gene expression in cultured mast cells. The IL-4R a-chain triggers two major activating signaling cascades, one through phosphorylation and nuclear transloca- tion of the transcription factor STAT6 and the other through Akt...
Dysregulation of IL-4 is directly associated with allergic diseases such as asthma, rhinitis and hay fever (Li-Weber and Krammer, 2003, Tepper et al., 1990). Recent studies on the mechanism of IL-4 gene regulation in T cells have demonstrated that the NFAT/AP1 complex has a critical ...
J.Barkans,C.J.Corrigan,R.Pfister,G.Menz,M.Larche,D.S.Robinson,S.R.Durham and A.B.Kay.1997.Expression of IL-4 and IL-5 mRNAand protein product by CD4+and CD8+T cells,eosinophils,and mast cells in bronchialbiopsies obtained from atopic and nonatopic(intrinsic)asthmatics.J.Immunol....
(intrinsic)asthmatics. J. Immunol. 158 :3539_3544.2. Huang, S. K. , H. Q. Xiao, J. Kleine-Tebbe, G. Paciotti, D. G. Marsh, L. M. Lichtenstein and M. C. Liu. 1995. IL-13expression at the sites of allergen challengein patients with asthma. J. Immunol. 155 :2688_2694.3. ...
IL4RA gene expression in relation to I50V, Q551R and C-3223T polymorphisms. Danielewicz, Dębińska, Drabik-Chamerska, Kalita, Boznański, Adv Clin Exp Med(2021 Jan) Intranasal IL-4 Administration Alleviates Functional Deficits of Periventricular Leukomalacia in Neonatal Mice. Yu, Miao, Li...