IL-27p28 subunit, also known as IL-30, was initially discovered as an IL-27-specific subunit, and it has thus been deemed as a surrogate marker to denote IL-27 expression. However, IL-30 can be secreted independently of Ebi3, a subunit that forms bioactive IL-27 with IL-30. More...
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IL-27p28基因多态性克罗恩病研究背景与目的 克罗恩病(Crohn disease CD)是一种慢性非特异性胃肠道炎症性疾病,其病因和发病机制尚未完全阐明,目前认为是由环境,遗传,感染,免疫等多种因素相互作用所致.近年来研究发现,肠道黏膜免疫异常在炎症性肠病(Inflammatory bowel disease, IBD)发生发展过程中起重要作用,其中细胞...
The serum levels of IL-27 in the participants were determined using enzyme-linked immunosorbent assay. Results: Our results did not show a significant relationship between IL-27p28 SNPs (rs153109 and rs181206) and the risk of AR or serum IL-27 levels. However, our result...
A role for IL-27p28 as an antagonist of gp130-mediated signaling. Nat Immunol. 2010;11(12):1119–1126. View this article via:Stumhofer JS, Tait ED, Quinn WJ 3rd, Hosken N, Spudy B, Goenka R, Fielding CA, O’Hara AC, Chen Y, Jones ML, Saris CJ, Rose-John S, Cua DJ, ...
Genomic DNA was extracted from blood samples using the QIAamp DNA Blood Mini kit, then the PCR products of IL27 and IFITM3 were cut by FastDigest XhoI and MScI, respectively, for detection of SNPs of IL-27P28 rs153109 (-964A/G) and IFITM3 rs12252 (T>C).The present study found ...
目的评估IL-27基因多态性和血清IL-27p28水平与骨肉瘤风险的相关性.方法对比研究160例骨肉瘤患者(研究组)和250例健康患者(对照组).IL-27基因-964 A/G,2905 T/G,和4730 T/C多态性采用聚合酶链反应-限制性片段长度多态性测定.酶联免疫吸附试验检测血清中IL-27p28的水平.结果与对照组相比,骨肉瘤患者血清IL-...