IL-27 receptor-regulated stress myelopoiesis drives abdominal aortic aneurysm developmentInterleukinsHaematopoietic stem cellsAneurysmAbdominal aortic aneurysm (AAA) is a prevalent life-threatening disease, where aortic wall degradation is mediated by accumulated immune cells. Although cytokines regulate ...
(known as IL-30). IL-27 is produced by antigen-presenting cells. IL-27 plays an important function in regulating the activity of B and T lymphocytes. The effects of IL-27 are eliciting by its interaction with a specific cell surface receptor complex composed of two proteins known as IL27...
Recombinant Interleukin 27 Receptor Alpha (IL27Ra) 白介素27受体α(IL27Ra)重组蛋白 [ PROPERTIES ] Source: Prokaryotic expression Host: E.coli Residues: Glu123~Pro343 Tags: N-terminal His Tag Subcellular Location: Membrane Purity: > 97% Traits: Freeze-dried powder Buffer formulation: PBS, pH...
ve CD4+ T cells, IFN-γ production, and Th1 polarization. IL-27 elicits its effects through receptor complexes IL-27R (also known as TCCR/WSX-1) and gp130, a receptor shared by IL-6. Mainly expressed in monocytes, endothelial cells, and dendritic cells, IL-27 plays an important role ...
的分泌。当DCs表面的Toll样受体(Tolllikereceptor,TLR)受 到外界信号刺激的时候,通过激 活下游因子MyD88、IRF3、c-Rel以及JNK等通路介导IL-27表达。 IL-27受体由WSX-1和gp130两个 亚基组成,表达于多种免疫细胞和非免疫细胞表面。IL-27对这些细 胞的发育、分化和功能都发挥着不 可或缺的作用。IL-27与其受体...
Monocytes expressed gp130 and WSX-1, the two chains of IL27 receptor (R), and IL6R (that serves as IL-30R, in combination with gp130). However, only IL27R appeared to be functional, as witnessed by IL-27 driven STAT1/ STAT3 phosphorylation. IL-27, but not IL-30, significantly up...
However, IL-27 sensitizes NK cells to augment bothandresponses mediated via the NKG2D receptor. This 'priming' function of IL-27 is mediated partly via transcriptional pathways regulated by Mafs and Nrf2 transcriptionally regulating TFAM and CPT1. Our data for the first time establishes a novel ...
Identification and molecular characterization of fractalkine receptor CX3CR1, which mediates both leukocyte migration and adhesion. Cell 91, 521–530 (1997). Article CAS Google Scholar Rosenwald, M., Perdikari, A., Rulicke, T. & Wolfrum, C. Bi-directional interconversion of brite and white ...
(4) IL-27 receptor complex (WSX-1/TCCR and gp130) were co-expressed in U266 and RPMI8226 cell lines surface. (5) rhIL-27 inhibited the proliferation of U266 and RPMI8226 cell lines in a time- and dose-dependent manner. After the treatment of ...
白介素27(IL27)重组蛋白 Recombinant Interleukin 27 (IL27) p28; IL30; Interleukin 30; Interleukin-27 subunit alpha 物种 Homo sapiens (Human ,人) 来源 原核表达 宿主 E.coli 内毒素水平 <1.0EU/μg(LAL