The purpose of the present invention is to provide a novel IL-2 variant that has an improved selectivity for IL-2Rαβγand selectively activates Treg. The present invention pertains to: an IL-2 variant; a method for producing the IL-2 variant; a composition containing the IL-2 variant;...
参考文献 1. Antoine I, Loic V, Hans P, M. G Eva, Diego T, Ruth P, et al. Clinical activity and safety of simlukafusp alfa, an engineered interleukin-2 variant targeted to fibroblast activation protein-α, combin...
Another promising IL-2 variant with site-specific PEGylation, designated dual 31/51-20 K, similarly displayed substantially increased clearance half-life, preferentially stimulated Tregover effector T cells compared with unmodified IL-2 by selectively reducing the binding affinity for the β subunit ...
The IL-2 variant H9T inhibits T cell exhaustion and promotes the induction of T cell stemness by acting as a partial agonist. Questions answered in this articleBetaPowered by GenAIThis is generative AI content and the quality may vary. Learn more. What were the comparative effects of wild-...
Stabilized interleukin 2 优选的的制剂包含甘氨酸和蔗糖并且IL-2变体具有一个突变,N88R. Preferred formulations comprise glycine and sucrose and IL-2 variant has a mutation, N88R. ... W·王,W・王,R·纳亚,... 被引量: 4发表: 2004年 ...
Recombinant Human IL-2 produced in E.Coli is a single, non-glycosylated mutein (variant form) of human IL-2 polypeptide chain containing 134 amino acids and having a molecular mass of 15517 Dalton. Our rHuIL-2 has an Ser substitute for Cysteine at position 126. The rHuIL-2 is purified ...
This study identifies the functional importance of a non-coding autoimmunity risk variant in the IL2RA gene and shows that the kinetics of IL2RA gene expression can be important for disease development. Article CAS PubMed PubMed Central Google Scholar Burren, O. S. et al. Chromosome contacts...
Interleukin-2 Human Recombinant produced in E.Coli is a single, non-glycosylated mutein (variant form) of human IL-2 polypeptide chain containing 134 amino acids and having a molecular mass of 15517 Dalton. Our Interleukin -2 has an Ser substitute for Cysteine at position 126. ...
IL-2受体分为高亲和力和低亲和力受体。IL-2与NK细胞和T淋巴细胞上表达的三种受体复合物识别,其中低亲和力受体仅由IL-2Rα链组成,不会触发细胞内信号级联反应,中等亲和力受体由IL-2Rβ链和共同的γc链组成,高亲和力受体由IL-2Rα、IL-2Rβ链和共同γc链组成;IL-2与中/高亲和力受体的结合将导致Janus激酶1(...
P. et al. Rational development of LEA29Y (belatacept), a high-affinity variant of CTLA4-Ig with potent immunosuppressive properties. Am. J. Transpl. 5, 443–453 (2005). Article CAS Google Scholar Watkins, B. K. et al. CD28 blockade controls T cell activation to prevent graft-versus-...