由于肿瘤转移是患者死亡的主要原因,作者将重点放在对侵袭和迁移至关重要的基因上。为有效敲除这50个基因,利用内切核糖核酸酶制备的siRNA文库,检测了在常氧或缺氧条件下,每个基因对MDA-MB-231细胞侵袭的影响。通过结合生长在I型胶原上的细...
四、参考文献: Inhaled siRNA nanoparticles targeting IL11 inhibit lung fibrosis and improve pulmonary function post-bleomycin challenge.PMID:35731866 Targeting endogenous kidney regeneration using anti-IL11 therapy in acute and chronic models of kidney disease.PMID:36470928 IL11 activates the placental infla...
Transient IL-11-KO Tie-GFP mice were generated as follow; For in vivo RNAi studies, IL-11 siRNA (ID AM16832, Ambion) or non-targeting control siRNA (Cat#: 4404021, Ambion) were reconstituted (5 µg/µl) in nuclease-free water and administered to the lungs to 24 weeks old mice ...
Bai, X.; Zhao, G.; Chen, Q.; Li, Z.; Gao, M.; Ho, W.; Xu, X.; Zhang, X.Q. Inhaled siRNA nanoparticles targeting IL11 inhibit lung fibrosis and improve pulmonary function post-bleomycin challenge.Sci. Adv.2022,8, eabn7162. [Google Scholar] [CrossRef] ...
特异性siRNA下调PC9和H1975细胞中的EGFR表达时,mRNA和蛋白质水平的ILT4表达均下降。鉴于配体结合是EGFR激活的一种模式,我们研究了EGF对ILT4的调节,EGF是EGFR的经典配体。在EGFR野生型H1299细胞中。我们发现 EGF 刺激以剂量依赖性方式从 0 到 100 ng/mL 上调 ILT4 表达,其中 100 ng/mL EGF 导致 ILT4 表达最...
Inhaled siRNA nanoparticles targeting IL11 inhibit lung fibrosis and improve pulmonary function post-bleomycin challenge. Authors - Xin Bai KD Validated View Article human,mouse IHC Life Sci The effect of hepatic stellate cell derived-IL-11 on hepatocyte injury in hepatic fibrosis Authors - Ling-Feng...
CAS号: 英文名: IL-11Rα siRNA (m) 英文别名: IL-11Rα siRNA (m) 中文名: 中文别名: CBNumber: CB09720675 分子式: 分子量: 0 MOL File: Mol file 化学性质 安全信息 用途 供应商 1 IL-11Rα siRNA (m)化学性质 安全信息...
Inhaled siRNA nanoparticles targeting IL11 inhibit lung fibrosis and improve pulmonary function post-bleomycin challenge. Sci. Adv. 2022, 8, eabn7162. [Google Scholar] [CrossRef] [PubMed] Allanki, S.; Strilic, B.; Scheinberger, L.; Onderwater, Y.L.; Marks, A.; Günther, S.; ...
To identify genome-wide downstream targets of MAFF in tumor cells that are involved in tumor invasion and metastasis, we performed high throughput RNA-sequencing of MDA-MB-231 cells exposed to normoxia or hypoxia for 24 hours, with or without genetic inhibition of MAFF by siRNA. When MAFF ...
Lastly, targeted delivery of ALKBH5 or IL-11 receptor 伪 (IL11RA1) siRNA to monocytes/macrophages attenuates MMT and cardiac fibrosis under hypertensive stress. Our results thus suggest that the ALKBH5/IL-11/IL11RA1/MMT axis alters cardiac macrophage and contributes to hypertensive cardiac ...