由于肿瘤转移是患者死亡的主要原因,作者将重点放在对侵袭和迁移至关重要的基因上。为有效敲除这50个基因,利用内切核糖核酸酶制备的siRNA文库,检测了在常氧或缺氧条件下,每个基因对MDA-MB-231细胞侵袭的影响。通过结合生长在I型胶原上的细...
四、参考文献: Inhaled siRNA nanoparticles targeting IL11 inhibit lung fibrosis and improve pulmonary function post-bleomycin challenge.PMID:35731866 Targeting endogenous kidney regeneration using anti-IL11 therapy in acute and chronic models of kidney disease.PMID:36470928 IL11 activates the placental infla...
Transient IL-11-KO Tie-GFP mice were generated as follow; For in vivo RNAi studies, IL-11 siRNA (ID AM16832, Ambion) or non-targeting control siRNA (Cat#: 4404021, Ambion) were reconstituted (5 µg/µl) in nuclease-free water and administered to the lungs to 24 weeks old mice ...
Inhaled siRNA nanoparticles targeting IL11 inhibit lung fibrosis and improve pulmonary function post-bleomycin challenge. Authors - Xin Bai KD Validated View Article human,mouse IHC Life Sci The effect of hepatic stellate cell derived-IL-11 on hepatocyte injury in hepatic fibrosis Authors - Ling-Feng...
CAS号: 英文名: IL-11Rα siRNA (m) 英文别名: IL-11Rα siRNA (m) 中文名: 中文别名: CBNumber: CB09720675 分子式: 分子量: 0 MOL File: Mol file 化学性质 安全信息 用途 供应商 1 IL-11Rα siRNA (m)化学性质 安全信息...
Lastly, targeted delivery of ALKBH5 or IL-11 receptor 伪 (IL11RA1) siRNA to monocytes/macrophages attenuates MMT and cardiac fibrosis under hypertensive stress. Our results thus suggest that the ALKBH5/IL-11/IL11RA1/MMT axis alters cardiac macrophage and contributes to hypertensive cardiac ...
Specifically, siRNA-mediated knockdown of IL-11 sensitized the cells to paclitaxel-induced cell death, while anti-IL-11 antibody added to culture medium increased doxorubicin-induced apoptosis. Indeed higher IL-11 expression was associated with reduced progression-free and overall survival in a cohort...
Transfection of Lentivirus vector or siRNA interference. Lentivirus vector expressing IL-11(LV-IL-11) and negative control were purchased from Realgene Company (Nanjing, Jiangsu). Lentivirus vector with shRNA targeting IL-11 receptor ( LV- IL-11RαRNAi target 5′-GGACCATACCAAAGGAGAT...
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As anticipated, siRNA-mediated knockdown of TWF1 inhibited IL-11 mRNA and protein expression in MDA-MB-231 cells, similar to the effect of miR-30c on IL-11 (Fig. 5e,f). These data suggest that IL-11 is an important target of TWF1 in the miR- 30c signalling pathway, which ...