In a recent study published in Nature, 1 Widjaja et al. show that blocking the age-related increase in IL-11 restores immune-metabolic homeostasis and extends healthspan and lifespan in mice.Hee-Hoon KimVishwa Deep DixitCell Metabolism
Longevity leap: mind the healthspan gap. NPJ Regen. Med. 6, 57 (2021). Article CAS PubMed PubMed Central Google Scholar Sukoff Rizzo, S. J. et al. Assessing healthspan and lifespan measures in aging mice: optimization of testing protocols, replicability, and rater reliability. Curr. ...
Unlocking longevity: How blocking IL‐11 signaling could extend healthspan and lifespan doi:10.1002/mef2.101Medcomm: Future MedicineLok, L. S. C.Monteiro, O.Baptista‐Hon, D. T.
IL-11 is upregulated with age We determined IL-11 expression in the liver, visceral gonadal white adipose tissue (vWAT) and skeletal muscle (gastrocnemius) in mice over a time course of ageing, which revealed progressive up-regulation of IL-11 in all tissues (Fig.1b,cand Extended Data Fig...
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Involved in mitochondrial quality control after oxidative damage, and in subsequent cellular longevity. The ATG12-ATG5 conjugate also negatively regulates the innate antiviral immune response by blocking the type I IFN production pathway through direct association with RARRES3 and MAVS. Also plays a ...
If you're using rosin-core solder, wait till the tip stops smoking. The solder glob protects the tip from getting dirty or oxidized, increasing its longevity. 清理 完成所有引线的焊接后,使用平口钳修剪焊点上方的引线。 关掉烙铁之前,在烙铁头上留一团焊锡(给烙铁头镀锡)。如果您使用的是松香芯焊锡...
Haruhiko TokudaDepartment of Internal Medicine, Chubu National Hospital: National Institute for Longevity Sciences, Obu, JapanTakehiro KaidaDepartment of Pharmacology, Gifu University School of Medicine, Gifu, JapanToshihiko UematsuDepartment of Pharmacology, Gifu University School of Medicine, Gifu, Japan...