Specifically, siRNA-mediated knockdown of IL-11 sensitized the cells to paclitaxel-induced cell death, while anti-IL-11 antibody added to culture medium increased doxorubicin-induced apoptosis. Indeed higher IL-11 expression was associated with reduced progression-free and overall survival in a cohort...
A donor-specific antibody was found in the one patient without expansion. In pts with tumor regression at day +30 compared to those without, CD56dimCD16+ NK cell clusters expanded by day +14 (93.7% vs. 37.3% of PB NK cells). The CD16+KIR+CD57+ NK cell cluster was more prevalent ...