IL-1受体相关激酶-M1. And Toll-like receptor 4(TLR4) plays a vital role in endotoxin signaling;Meanwhile the Interleukin-1 receptor-associated kinase-M(IRAK-M) is a important negative-regulator in the signaling. 而IL-1受体相关激酶-M(IRAK-M)则是信号传导途径中重要的负调节因子。