The NLRP3 inflammasome was activated after ICH and was located in the microglial cell of the mouse brain, which exhibits a time-dependent manner. However, the number of NLRP3/Iba-1 dual-labeled cells in the C3−/− group is less than that in the WT group in each time course, ...
A mutation in the inflammasome protein NLRP3 (NACHT, LRR and PYD domains-containing protein 3) causes excess production of IL-1β, resulting in an ... SY Woo - 《International Immunology》 被引量: 258发表: 2012年 Gene polymorphisms in the NALP3 inflammasome are associated with interleukin-1...
human,mouseWB Nat Cell Biol Myeloid PTEN promotes chemotherapy-induced NLRP3-inflammasome activation and antitumour immunity. human,mouseWB Nat Commun CLICs-dependent chloride efflux is an essential and proximal upstream event for NLRP3 inflammasome activation. ...
3.3. NLRP3 Inhibitor CRID3 Decreases IL-1β Secretion during NADL cp-BVDV Infection To determine whether the NLRP3 inflammasome participates in the secretion of IL-1β during infection with the BVDV, we used the inhibitor CRID3 (50 µM), which interferes with the activation of NLRP3 upstr...
THE ATTENUATION OF IL‐1BETA RESPONSE IN MAC‐LD IS DUE TO BOTH DECREASES OF NLRP3 INFLAMMASOME AND TLR2 ACTIVATIONinflammasomeactivation pathwaytranscription pathwaymacrophageMycobacterium avium complexdoi:10.1111/resp.13207_30NoneJohn Wiley & Sons, LtdRespirology...
Conclusions These findings suggest that oxLDL-induced NLRP3 inflammasome activation mainly depends on CD36 involved in the progression of atherosclerosis by promoting oxLDL-mediated inflammation and foam cell formation. 展开 关键词: Vascular disease oxLDL IL-1β NLRP3 inflammasome CD36 Foam cells ...
The inflammasome is a multi-protein complex made of a PRR, such as Nod-like receptor family, pyrin domain containing 3(NLRP3), an adaptor, such as apoptosis-associated spec-like protein containing a CARD (ASC), and pro-caspase-1 (1-3,5). Assembly of the inflammasome enables cleavage of...
Omega-3 fatty acids prevent inflammation and metabolic disorder through inhibition of NLRP3 inflammasome activation. Authors - Yiqing Yan View Article zebrafish IF Cell Migratory Neural Crest Cells Phagocytose Dead Cells in the Developing Nervous System. Authors - Yunlu Zhu View Article WB Trends Biot...
The inflammasome is a multi-protein complex made of a PRR, such as Nod-like receptor family, pyrin domain containing 3(NLRP3), an adaptor, such as apoptosis-associated spec-like protein containing a CARD (ASC), and pro-caspase-1 (1-3,5). Assembly of the inflammasome enables cleavage of...
8-Target type 9-Primary research area 10-Other research areas 11-Molecular weight The precursor is cytosolic. In response to inflammasome-activating signals, such as ATP for NLRP3 inflammasome or bacterial flagellin for NLRC4 inflammasome, cleaved and secreted. IL1B lacks any known signal sequence...