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IL-1 signaling can be activated by the interaction between IL-1β and IL-1 receptor (IL-1R), leading to various immune responses including neutrophilic inflammation47. Here we deployed recombinant IL-1β on air-liquid interface (ALI) cultures generated from primary human nasal epithelial cells (...
During steady state, Aim2 deletion results in the loss of IL-18 secretion, suppression of the IL-22 binding protein (IL-22BP) in intestinal epithelial cells and consequent loss of the STAT3-dependent antimicrobial peptides (AMPs) Reg3β and Reg3γ, which promotes dysbiosis-linked colitis. ...
Wnt signaling has been shown to be important for the self-renewal and function of Lgr5+ ISCs (Li et al., 2018; Mah et al., 2016; Yin et al., 2014). Therefore, the initial activation of Wnt signaling in stem cells may be involved in IL-17RA-mediated induction of Atoh1 and ...
Upon reaching confluency state, cells were plated and prepared for treatment. The cells were grown in DMEM/F12 serum-free media (SFM) for 6 h before treatment addition. Measurement of cell viability MTT assay was performed by examining the ability of living cells to convert the tetrazolium dye...
NameCallsRenewal Period API calls per connection 100 60 secondsActionsהרחב טבלה Decode a vehicle plate Retrieves a library of vehicle's data based on the vehicle's registration/license plate number and state. The state is a two letter abbreviation, with international supp...
the roles of the AIM2 inflammasome in IBD and the early phases of colorectal cancer remain ill-defined. Here we show that the AIM2 inflammasome has a protective role in the intestine. During steady state,Aim2deletion results in the loss of IL-18 secretion, suppression of the IL-22 binding...
in NOD/SCID IL2Rg null mice by regulating Bmi-1 and microRNA-128 R Nanta1, D Kumar1, D Meeker1, M Rodova2, PJ Van Veldhuizen2, S Shankar3 and RK Srivastava1 Prostate cancer stem cells (CSCs) are defined by their extensive self-renewal, differentiation and tumor initiation properties....
et al. Jagged1 signals in the postnatal subventricular zone are required for neural stem cell self-renewal. EMBO J 24, 3504–3515 (2005). 14. Amsen, D. et al. Instruction of distinct CD4 T helper cell fates by different notch ligands on antigen-presenting cells. Cell 117, 515–526 (...
Unex- pectedly, Tsc1 deletion resulted in a twofold increase in the frequency of proliferating cells, as determined by the incorpora- tion of bromodeoxyuridine (BrdU) and by staining with the proliferation marker Ki67 under steady-state conditions (Fig. 4a,b). Using Fucci-2 reporter mice, ...