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IL-1 family cytokines can act differently across various diseases, which necessitates precise targeting by therapeutic drugs. These drugs have generally been safe and well-tolerated, with mostly mild to moderate side effects. Nonetheless, developing more effective drugs with fewer side effects is an ...
In conclusion, Ad-TD-nsIL12 is a safe agent for patients with rHGG that is connecting with the ventricles, as commonly occurs in recurrent cases after resection. Moreover, Ad-TD-nsIL12 could be administered repeatedly without safety concerns. Administration via either an Ommaya reservoir or by...
The safe dose of rhIL-18BP for animal studies was selected according to the AFRRI toxicity study protocol (modified “up and down” procedure, UDP). A single dose of rhIL-18BP (0.25, 0.5, 1.0, 1.5, 2.0, 3.0 or 5.0 mg/kg body weight)21,32 or saline vehicle in 0.1 mL total ...
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2023 : Pour apaiser les craintes relatives à la confidentialité des données, TikTok a proposé deux nouvelles initiatives, Project Clover et Project Texas, dans le cadre desquels les données relatives aux utilisateurs américains et européens seraient retenues, stockées et gérées localement...
In the work performed by Bafadhel et al.,sputumIL1Bwas the most sensitive and specific biomarker for detecting a pro-inflammatory bacteria-associated exacerbation (Bafadhel et al., 2011b).Monoclonal antibodiesto target the IL1 pathway were safe but not associated with an improvement of exacerbati...
none of these were found to be expressed by all the Breg populations or to act as a common identifying marker. Among their various functions, Bregs maintain the balance between Tregs and Th1/Th17 populations; in addition, they prevent differentiation of naive T cells into Th1 and Th17 while ...
NLRP3 inhibitors also appear to be safe and have a short half-life, allowing for rapid discontinuation of treatment in the event of side effects. However, these small molecules act intracellularly and are therefore more likely to have off-target effects than IL-1 antagonists. The processing of...
Cytokine-encoding DNA plasmids can act as ‘genetic adjuvants’, improving the immune response stimulated by co-administered DNA vaccines. We examined whether plasmids encoding the Th1 cytokine IFNγ (pIFNγ) or the Th2 cytokine IL-4 (pIL-4) have long-term effects on immune homeostasis when ...