Locus of (IL-9) control: IL9 epigenetic regulation in cellular function and human disease Article Open access 03 June 2024 References Elaraj, D. M., Weinreich, D. M., Varghese, S., Puhlmann, M., Hewitt, S. M., Carroll, N. M. et al. The role of interleukin 1 in growth and...
This unstable phenotype was associated with a strong methylation of the Treg-specific demethylated region within the Foxp3 locus. Administration of IL-2/anti-IL-2 complexes expanded the numbers of transferred Foxp3(+) iTreg in the absence of Ag challenge. Notably, when the iTreg were ...
In this study, two previously indicated risk variants at the IL18RAP locus (rs13015714 and rs917997) were tested for genetic association in 1638 cases with coeliac disease and 1385 control individuals from the Finnish, Hungarian and Italian populations. The protein expression level of IL18RAP was...
Mutagenesis and Functional Characterization of the RNA and Protein Components of the toxIN Abortive Infection and Toxin-Antitoxin Locus of Erwinia▿ These mechanisms include the abortive infection systems, which promote "altruistic suicide" of an infected cell, protecting the clonal population. A cryptic...
Accumulation of senescent cells contributes to ageing pathologies. We modelled replicative senescence by serially passaging human fibroblasts in the presence of a neutralizing IL11RA antibody (X209) or an IgG control29,34. We observed passage-dependent phosphorylation of ERK–mTORC1, NF-κB and STAT3...
IL-2 was first identified as a growth factor capable of driving the expansion of activated human T cell populations. In the more than 40 years since its discovery, a tremendous amount has been learned regarding the mechanisms that regulate the expression of both IL-2 and its cell surface rece...
CD4 T cells of CNS1(-/-) mice showed IL-7Rα upregulation in the absence of growth factors and IL-7Rα downregulation by IL-7 or TCR stimulation, although the expression levels were lower than those in control mice. Naive CD4 and CD8 T cells of CNS1(-/-) mice show attenuated ...
Docetaxel resistance represents a significant obstacle in the treatment of prostate cancer. The intricate interplay between cytokine signalling pathways and transcriptional control mechanisms in cancer cells contributes to chemotherapeutic resistance, ye
IL-36c alters NFjB signaling and acetylation of the Foxp3 locus during iTreg cell differentiation We next investigated whether IL-36g may be mediating its effects on inhibiting iTreg cells by interfering with signaling downstream of TGFb receptor, specifically SMAD3, as it is known to bind the...
The modulation of pulmonary group 2 innate lymphoid cell function in asthma: from inflammatory mediators to environmental and metabolic factors. Exp Mol Med. 2023;55:1872–84. Article CAS PubMed PubMed Central Google Scholar Zhou L, Lin Q, Sonnenberg GF. Metabolic control of innate lymphoid ...