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et al. Self-renewal of CD133hi cells by IL6/Notch3 signalling regulates endocrine resistance in metastatic breast cancer. Nat. Commun. 7:10442 doi: 10.1038/ncomms10442 (2016). This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party...
In lung cancer, cisplatin resistance enhances self-renewal and induces M2 polarization of TAMs through the secretion of macrophage migration inhibitory factor [18]. Additionally, many studies have shown that chemotherapy treatment induces chronic inflammation and increases M2 macrophages in TME by ...
Wnt signaling has been shown to be important for the self-renewal and function of Lgr5+ ISCs (Li et al., 2018; Mah et al., 2016; Yin et al., 2014). Therefore, the initial activation of Wnt signaling in stem cells may be involved in IL-17RA-mediated induction of Atoh1 and ...
Under a Creative Commons license open accessAbstract Head and neck squamous cell carcinomas (HNSCC) exhibit a small population of uniquely tumorigenic cancer stem cells (CSC) endowed with self-renewal and multipotency. We have recently shown that IL-6 enhances the survival and tumorigenic potential...
The CSCs derived model may screen the cell population of high proliferation rate and self-renewal, which may better form the brain metastasis model. The model formation cycle and successful rate may also be improved. This brain metastasis model acquired the same character ...
Tumor cells take advantage of EMT as an intermediary phenotype to achieve self-renewal and to adapt to their microenvironments [40, 41]. Experimentally, EMT can be induced not only by loss of cellular contact (for example, due to degradation of basement membranes or other modifications of the...
The long noncoding RNA lncTCF7 promotes self-renewal of human liver cancer stem cells through activation of Wnt signaling. Cell Stem Cell. 2015;16(4):413–25. Article CAS PubMed Google Scholar Han X, Yang F, Cao H, Liang Z. Malat1 regulates serum response factor through miR-133 as ...
(Fig.1f). Among the identified subsets,LY6D+club cells have not been reported, while thePRB1+GC andMUC5B+GC subsets were previously observed in the nasal mucosa of CRSwNP patients15. Pathway enrichment analysis revealed thatPRB1+GCs are associated with erythrocyte renewal and metabolism, while...
and cancer stem cell self-renewal27,28. Previously, it was reported that upon cell adhesion to the ECM, activated integrins led to an increase in the phosphorylation of FAK29. In A549 cells, cell adhesion to laminin-10/11 mediated by α3β1 integrins also led to phosphorylation of FAK and...