(B, E, H) Dot plots showing expression levels of IL11 across different cell types within the prostate cancer microenvironment for datasets GSE137829, GSE141445, and GSE206962, respectively. The y-axis represents the expression level, and each dot represents a single cell. (C, F, I) Dot ...
Inflammatory factors are predominantly upregulated in response toNeisseria gonorrhoeaein human FTOC To understand the response of human Fallopian tube toN. gonorrhoeaeexposure, we performed RNA-Seq analysis on four donor tissues treated with cell-free supernatant from in vitro growth ofN. gonorrhoeae. Th...
Ferroptosis product 4HNE induces various types of host cell death The lipid peroxidation product 4HNE has been implicated in the etiology of pathological changes as a key mediator of oxidative stress-induced cell death. This reactive aldehyde species is a main product of lipid peroxidation during fe...
Our study not only sheds light on the synergy between these two types of immune responses, but also unveils an innovative strategy for advancing next-generation cancer immunotherapy by integrating type 2 immune factors.Similar content being viewed by others The antitumor activity of TGFβ-specific T...
In a 24-well plate, 600 μL of complete 1640 medium was meticulously introduced, and the Transwell inserts were gently inserted into the wells, taking care to prevent bubble formation. Subsequently, 200 μL of the single-cell suspension of neutrophils was uniformly dispensed into the Transwell ...
Thus, in this limited set of cell types examined, we have found no evidence to support the idea that some of the circulating sAcP is generated by shedding of the transmembrane form. Discussion The experiments presented in this paper reveal a previously unappreciated interaction between the soluble...
Furthermore, additional experiments are needed to address the question of the responsible cell types expressing IL-17RB in the retina. STAR★Methods Key resources table REAGENT or RESOURCESOURCEIDENTIFIER Antibodies Chicken polyclonal anti-MBP (WB: 1:8000IF: 1:2000) Novus Cat#NBP2-50035; RRID: ...
Also, we evaluated an important component tumor necrosis factor α (TNF-α), which can be secreted by different cell types through the stimulation with inflammatory mediators, or cytokines such as IL-1β. 2. Results 2.1. Cloning and Analysis of Full-Length IL-1β mRNA A PCR...
d) Box plot showing the proportion of the cell types in M4/M5 low (n = 5 patients), intermediate (n = 3 patients) and high groups (n = 3 patients), as detected by scRNAseq; box and whisker plots display median, upper and lower quartiles, and range. e) FACS ...
Macrophages and other cell types such as epithelial cells, airway smooth muscle cells and endothelial cells produce IL-8. There are many receptors on the surface membrane capable of binding IL-8; the most frequently studied types are the G protein-coupled serpen- tine receptors CXCR1 and CXCR...