Interestingly, we found that the total amount of TGF-β1, and the active form of TGF-β1 was increased in the tumor tissue, compared with normal adjacent tissue control (Fig. 1A). We then analyzed the presence of IL-22 producing CD4+ T cells isolated from the same cohort of patients....
BMC Pulmonary Medicine (2024) 24:70 https://doi.org/10.1186/s12890-024-02885-2 BMC Pulmonary Medicine RESEARCH Open Access Adverse events of anti‑IL‑5 drugs in patients with eosinophilic asthma: a meta‑analysis of randomized controlled trials and real‑world evidence‑...
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The splice variant formed by an alternative terminator in exon 10.2 generates the 356-amino-acid-long soluble form of IL1RAP, sIL1RAP, which lacks the transmembrane and intracellular domain, whereas the splice variant derived from terminator in exon 13 encodes the 570-amino-acid membrane form ...
Am J Physiol Lung Cell Mol Physiol 2005; 288 :L1040–L1048.Faffe DS, Flynt L, Mellema M, Whitehead TR, Bourgeois K, Panettieri RA Jr, Silverman ES, Shore SA. Oncostatin M causes VEGF release from human airway smooth muscle: synergy with IL-1beta. Am J Physiol Lung Cell Mol ...
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Similarly, B cell–specific IL-6–deficient mice develop an attenuated form of EAE. Considering that autoantibody levels were unaffected, this specific depletion indicates that IL-6 production is one of the main nonantibody-mediated mechanisms of pathogenic B cells involved in the development of EAE...
Higher doses of IL-22 plasma levels have been associated with higher disease activity in IBD patients defined with clinical scores in a recent study by the SPARC registry [57]. In clinical trials evaluating the efficacy of risankizumab and brazikumab, two monoclonal antibodies targeting the IL...
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