immobilize 使(某物)不能移动 immobility 固定,静止 ex)A plaster cast holds a broken bone immoblie, allowing it to heal. 石膏绷带固定住骨折的骨头,以利于其恢复。 6.impact [im<in( =intensive) +pact( =fasten, agree)使劲系紧,捆紧...
Using a panel of conditional knockout mice, we found that only deletion of the IL-4 receptor IL-4Rα in early myeloid progenitors in bone marrow reduced tumour burden, whereas deletion of IL-4Rα in downstream mature myeloid cells had no effect. Mechanistically, IL-4 derived from bone ...
Rifas, L (1999) Bone and cytokines: beyond IL-1, IL-6 and TNF-alpha. Calcif Tissue Int 64: pp. 1-7Rifas L. Bone and cytokines: beyond IL-1, IL-6 and TNFa. Calcif Tissue Int 1999; 64: 1-7A. Rifas.Bone and Cytokines: Beyond IL-1, IL-6 and TNF-α[J]. Calcified Tissue...
Immune responses are crucial not only for host defence against pathogens but also for tissue maintenance and repair after injury. Lymphocytes are involved in the healing process after tissue injury, including bone fracture and muscle damage. However, the
It has been proposed that two distinct signals are required for the triggering of the precursors of antibody-forming bone marrow-derived cells (B cells): (... Dukor,P. - 《Journal of Experimental Medicine》 被引量: 119发表: 1974年 The matrix metalloproteinases (MMPS) in the decidua and fe...
To investigate the other possible roles that these cytokines may play in stimulating the bone resorption process, we examined the effect of TNF-α and IL-1β on cell–cell adhesion molecules, cadherins, in osteoblastic MC3T3-E1 cells. In this study, we investigated cadherin expression and the ...
(NLRP3) inflammasome and cytokine release. Pro-IL1β is cleaved by the inflammasome and caspase 1 into its active form, followed by release of both IL1β and TNFα from tissue resident monocytes and macrophages. IL1β recruits monocytes from the bone marrow— whose arrival and exposure to ...
A growing understanding of the bone remodeling process suggests that inflammation significantly contributes to the pathogenesis of osteoporosis. T cells and various cytokines contribute majorly to the estrogen deficiency-induced bone loss. Recent studies have identified the IL-12 cytokine family as ...
IL-6 and bone homeostasis On earth IL-6 promotes bone formation by enhancing the differentiation of osteoblasts precursors and by protecting osteoblasts from apoptosis.51,52,53,54,55 It protects against bone resorption by decreasing receptor activator of nuclear factor kappa B ligand (RANKL) expressi...
The objective of this study was to determine whether a biphasic scaffold loaded with a combination of a chemokine and bone marrow concentrate (BMC) could improve tissue regeneration in knee articular cartilage of beagles with cylindrical osteochondral defects. For this investigation, an osteochondral def...