The proangiogenic cytokine Interleukin-3 (IL-3) is released by inflammatory cells in breast and ovarian cancer tissue microenvironments and also acts as an autocrine factor for human breast and kidney tumor-derived endothelial cells (TECs). We have previously shown that IL-3-treated endothelial cel...
5,6anti-tumour immunity. Therefore, new strategies to induce TLSs are attractive, as most human tumours have fewer infiltrating immune cells (immunologically cold), rendering them resistant to current immunotherapies. However, in contrast to SLOs that are preformed, TLSs assemble de novo...
This would also begin to answer whether the slow recovery of CD4+ T cell niche is caused by retarded thymic output, possibly due to long-lasting tamoxifen effects, or because thymopoiesis is an intrinsically slow process, at least in adult mice. It has been reported that the depletion of ...
We analyzed IL-7R expression in a panel of primary T-ALL samples representative of distinct T-cell developmental stages according to the European Group for Immunological Characterization of Leukemias classification, which were obtained from pediatric or adult patients at the time of diagnosis (supplement...
The use of IL-2/JES6-1 Ab complex (IL-2 Ab Cx) has been considered as a potential therapeutic for inflammatory diseases due to its selective expansion of regulatory T cells (Tregs) in mice. Here, IL-2 Ab Cx was explored as a therapeutic agent to reduce joint inflammation induced by ...
malayi. These drugs were further evaluated against adult worms for checking loss of motility. The promising results obtained from these studies fascinated them to evaluate in house library of two series (A and B, Fig. 34) of molecules containing biguanide and triazene moieties. Series B was ...
More specifically, IL1RAP mediated disease can include but are not limited to acne, acute severe ulcerative colitis, adult-onset Still's disease, allergic rhinitis, gouty arthritis, juvenile arthritis, osteoarthritis, rheumatoid arthritis, systemic sclerosis, arthritis pain, asthma, atherosclerosis, ...
In adult worms, reducing the expression of the daf-2 gene prevents daf-2 from reducing the action of the daf-16 gene, in turn increasing longevity. To make things more interesting, if you get rid of - just the gonads, instead of the sac that holds them entirely -, you again get a ...
Somatically acquired JAK1 mutations in adult acute lymphoblastic leukemia J Exp Med., 205 (4) (2008), pp. 751-758 CrossrefView in ScopusGoogle Scholar 50 M Kontro, H Kuusanmäki, S Eldfors, et al. Novel activating STAT5B mutations as putative drivers of T-cell acute lymphoblastic leuke...
(i.v.) RvD2 in chronic pain using two mouse models of sciatic nerve injury-caused neuropathic pain and sarcoma-caused bone cancer pain. Expressions of spinal IL-17, CXCL1 and glial fibrillary acidic protein (GFAP) were evaluated to indicate the activation of astrocyte as pivotal drivers of ...