IL-4和IL-13都结合II型受体复合物,其由IL-4Rα和IL-13Rα1组成。IL-13还以比IL-13Rα1高的亲和力结合IL-13Rα2。辅助受体链(例如γc,IL-13Rα1)在不同的特定细胞类型上表达。这些细胞因子IL-4和IL-13与它们各自的受体复合物的结合导致蛋白激酶JAK1或JAK3或Tyk2的活化,并随后使转录因子STAT6磷酸化...
IL-4/IL-13 signaling beyond JAK/ STAT. J. Allergy Clin. Immunol. 105, 1063–1070 (2000). 38. Kaplan, M.H., Schindler, U., Smiley, S.T. & Grusby, M.J. Stat6 is required for mediating responses to IL-4 and for development of Th2 cells. Immunity 4, 313–319 (1996). 39....
To understand the negative regulation of IL-4 signaling, we determined the time course of IL-4-dependent Stat6 activation in hematopoietic and nonhematopoietic cell lines. Binding of IL-4 to its receptor on the cell surface results in Jak-dependent phosphorylation of tyrosine 641 residue of laten...
Rothman IL-4/IL-13 signaling beyond JAK/STAT. J Allergy Clin Immunol., 105 (2000), pp. 1063-1070 View PDFView articleView in ScopusGoogle Scholar 70 Fort M, Lesley R, Davidson N, et al. IL-4 exacerbates disease in a Th1 cell transfer model of colitis. J Immunol., 166 (2001), ...
Jiang H, Harris MB, Rothman P: IL-4/IL-13 signaling beyond JAK/STAT. J Allergy Clin Immunol 2000, 105(6 Pt 1):1063–1070. 43. Ueta M, Sotozono C, Inatomi T, Kojima K, Hamuro J, Kinoshita S: Association of combined IL-13/IL-4R signaling pathway gene polymorphism with Stevens...
IL-4/IL-13 signaling beyond Jak/Stat. J Allergy Clin Immunol. 2000;105(6):1063–70. Article CAS Google Scholar Suzuki A, Leland P, Joshi BH, Puri RK. Targeting of IL-4 and IL-13 receptors for cancer therapy. Cytokine. 2015;75(1):79–88. Article CAS Google Scholar Agdashian D...
IL-4/IL-13 signaling beyond JAK/STAT. J. Allergy Clin. Immunol. 105, 1063–1070, https://doi. org/10.1067/mai.2000.107604 (2000). 10. Donaldson, D. D. et al. The murine IL-13 receptor alpha 2: molecular cloning, characterization, and comparison with murine IL-13 receptor alpha 1....
尽管这些细胞因子都通过 JAK-STAT 信号通路发挥功能,但它们在生物学活性上却大相径庭。IL-12 与 IL-23 主要作为促炎/促刺激细胞因子,强化炎症信号,对免疫平衡及炎症反应至关重要。而 IL-27 兼具促炎和抗炎双重特性,促进 Th1 分化同时抑制 Th17 细胞发育,由于 IL-27 通过结合 gp130 受体发挥作用,也时常被归类...
5e) suggesting that β-glucan-induced JAK-STAT signaling reduces IL-23 secretion in DCs. Fig. 5: EphA2 signaling impairs IL-23 secretion in BMDCs. a Correlation of IL-23 kidney levels and cDC infiltration during candidiasis in WT and Epha2–/– mice. N = 5; combined data of two ...
IL-4 signals transcription of key regulators of cell-cycle progression in cardiomyocytes via signal transducer and activator of transcription 3 (Stat3). GR, on the contrary, inhibits this signaling system. Thus, our findings uncover an interplay between stress and immune signaling pathways critical ...