Zhao L, Jiang Z, Jiang Y, Ma N, Wang K, Zhang Y, et al. IL-22+ CD4+ T-cells in patients with active systemic lupus erythematosus. Exp Biol Med (Maywood) 2013;238:193-9.Zhao L, Jiang Z, Jiang Y et al. IL-22+CD4+ T-cells in patients with active sys...
(C) IL-21、IL-21联合IL-23或IL-1β可诱导Th22细胞分化和IL-22表达，转录因子STAT3、RORγt、AhR参与其调控。(D) 内源性TLR4配体刺激角质形成细胞分泌IL-23, IL-23与DC的IL-23R结合；活化的DCs进一步分泌IL-23，诱导CD4+ T细胞向Th22细胞分化。(E) 联合IL-6、IL-23、IL-1β、FICZ、TGF-βR抑制...
(C) IL-21、IL-21联合IL-23或IL-1β可诱导Th22细胞分化和IL-22表达,转录因子STAT3、RORγt、AhR参与其调控。 (D) 内源性TLR4配体刺激角质形成细胞分泌IL-23, IL-23与DC的IL-23R结合;活化的DCs进一步分泌IL-23,诱导CD4+ T细胞向Th22细胞分化。 (E) 联合IL-6、IL-23、IL-1β、FICZ、TGF-βR抑制...
早期肝纤维化（S0 - S2, n = 15）和进展期肝纤维化（S3 - S4, n = 3）的Th22细胞、IL-22 + Th17细胞、产生IL-22的CD3 + CD8 - T细胞、Th17细胞、Th1细胞的频率，以及血浆IL-22水平相当（图2E）。图2：慢性HBV感染者的产生IL-22的CD3 + CD8 - T细胞频率、IL-22水平与肝脏炎症呈正相关表2：接...
谢青教授的博士研究生赖荣陶在开展本研究中发现CD4+T辅助细胞Th22、Th17在急性DILI患者,尤其是肝细胞损伤型患者中明显升高,两种细胞各自的效应分子IL-22及IL-17在DILI患者肝内的表达明显增加,尤其是肝内IL-22与炎症损伤、坏死程度存在密切正相关性,提示Th22细胞及IL-22在急性DILI炎症及免疫病理损伤中发挥重要作用。
《Th22/IL-22激活JAK2/STAT3信号促进高血压肾间质纤维化发生机制》是依托中南大学，由唐荣担任项目负责人的青年科学基金项目。项目摘要 CD4+T细胞及其分泌的炎症因子参与了高血压肾间质纤维化的进展。我们发现，高血压肾损害大鼠肾组织Th22细胞及其效应因子IL-22表达明显升高，与肾脏病理损伤呈...
In M. bovis-infected animals, PPDB specific IL-22 and IL-17A responses were observed in both CD4+ T cell and γδ T cell populations. Although both cytokines were detected in both cell types, IL-22/IL-17A double producers were rare and confined mainly to the γδ T cell population. ...
Naturally occurring CD4+CD25+FoxP3+ T regulatory (Treg) cells require three distinct signals transduced via TCR, CD28, and IL-2R for their development and maintenance. These requirements served as the basis for several recently developed ex vivo expansion protocols that relied on the use of solid...
流式检测结果显示卵巢癌患者肿瘤组织中CD4+细胞和TILs-Th22频率显著升高,且与肿瘤分期呈正相关;免疫荧光激光共聚焦结果显示卵巢癌肿瘤组织中IL-22主要由CD4+细胞分泌.细胞共培养结果表明总TILs和CD4+TILs可分泌IL-22,进而活化STAT3通路并诱导下游分子表达.结论Th22细胞通过释放IL-22活化STAT3信号通路促进卵巢癌的发展...