IL-17 inhibitorPASIPsoriasisPsoriasis is a common chronic, inflammatory skin condition. The pathogenesis of psoriasis involves many cytokines in the IL-17 family and their subsequent signaling cascade; therefore, IL-17 inhibitors may have utility in the treatment of psoriasis. This review aims to ...
近期,吴佳纹教授团队在Dermatitis 发表了题为Effect of the JAK1 Inhibitor, Upadacitinib, on Skin Barrier Repair of Eczema Elicited During Anti-Interleukin-17 Treatment for Psoriasis。通过皮肤屏障指标,研究评估了JAK抑制剂乌帕替尼治...
UCB has been bringing up the rear in the IL-17 inhibitor category with bimekizumab, but now has EU approval for the drug and thinks it can mount a stiff challenge to the leaders, including Novartis' big-selling Cosentyx. The European Commission has clear
A case of ustekinumab-induced pustular psoriasis was treated with IL-17A inhibitor LIN Junjie1, OU Min2, LI Yang1, SHE Xinyan1, CAI Liting1, GUAN Zepu1, WANG Xiaohua1 Author information + 文章历史 + 摘要 报告1例IL-17A抑制剂治疗乌司奴单抗诱发的脓疱型银屑病。患者女,51岁,因全...
探究IL-24如何调节免疫细胞(如T细胞、巨噬细胞、树突状细胞等)的激活和分泌细胞因子,从而影响BP的免疫损伤过程;②探究IL-24在BP患者中的免疫学特征,如其对免疫耐受性及抗体产生的影响;③IL-24与其他细胞因子的交互作用:深入研究IL-24与其他免...
参考资料: [1] Novartis' Cosentyx is first and only IL⑴7A inhibitor to potentially modify the course of psoriasis [2] Novartis官方网站
Description: The eBio17B7 antibody reacts with mouse and rat IL-17A with no recognition of IL-17F. Interleukin-17A (IL-17A) is a CD4+ T cell-derived cytokine that promotes inflammatory responses in cell lines and is elevated in rheumatoid arthritis, asthma, multiple sclerosis, psoriasis,...
it is reasonable to follow the established protocols for psoriasis vulgaris. It is recommended that the guideline-compliant therapy option with an IL-17 inhibitor be employed regarding efficacy, safety, and tolerability. In the interim period preceding the commencement of systemic therapy, local therap...
(IκBζ), which drives transcription. IκBζ levels are increased by IL-17 via transcriptional and translational induction; IL-17 further induces the mRNA and protein syntheses of numerous target genes in cooperation with NF-κB,51and inhibits miR-23b (an IL-17 signaling inhibitor) to promote...
Interleukin inhibitor iMTA: Institute for Medical Technology Assessment ITT: Intention to treat LOCF: Last observation carried forward MCQ: Medical Consumption Questionnaire NI: Non-inferior NMB: Net monetary benefit PASI: Psoriasis Area and Severity Index PCQ: Productivity Cost Questionnaire ...