摘要:目的探讨白介素10(interleukin10,IL10)对转化 生长因子β(tratormgrowthfactorbeta,TGFβ)刺激成纤维 细胞增殖、胶原分泌以及向肌成纤维细胞(myofibroblast,MFB)转化 的影响。方法培养人胚肺成纤维细胞,根据不同的处理方法分为五 组:A组加入TGFβ(5ng/ml),B组加TGFβ(5ng/ml)+IL10 ...
More recent work validates the potent immunomodulatory molecules transforming growth factor-beta (TGF-尾) and interleukin-10 (IL-10) as key targets for AD pharmacotherapy. Methods: We have crossed transgenic mouse models of AD with mice bearing genetically engineered immune/inflammatory genes targeting...
目的探讨白介素-10(interleukin-10,IL-10)对转化生长因子-β(transtorm growth factor beta,TGF-β)刺激成纤维细胞增殖,胶原分泌以及向肌成纤维细胞(myofibroblast,MFB)转化的影响.方法培养人胚肺成纤维细胞,根据不同的处理方法分为五组:A组加入TGF-β(5 ng/ml),B组加TGF-β(5 ng/ml)+IL-10(5 ng/ml)...
1、TGF-和IL-10在呼吸道合胞病毒毛细支气管炎患儿外周血中的含量及表达意义 摘要 目的 观察呼吸道合胞病毒毛细支气管炎患儿外周血中TGF-及IL-10的含量,并对其临床意义进行探讨。方法 选择2012年10月2013年10月间河北医科大学附属邢台市人民医院80例呼吸道合胞病毒毛细支气管炎检测为阳性的患儿为观察对象组,并以...
分类号:R587.1密级:◎,∥■单位代码:10422学号:200712792囊办呈硕士学位论文ShandongUniversityMaster'sThesis论文题目:成人隐匿性自身免疫性糖尿病患者血清IL一10、TGF—p水平及其与胰岛p细胞功能的关系EXPRESSIONSOFIL一10ANDTGF・pANDTHEIRRELATIONSWITHISLETBETACELLFUNCTIONINADULTESWITHLATENTAUTOIMMUNEDIABETES作者专业导师...
IL-13 Activates a Mechanism of Tissue Fibrosis That Is Completely TGF-{beta} Independent. J Immunol 2004; 173:4020–29 PubMed CAS Google Scholar Baumgart M, Tompkins F, Leng J and Hesse M. Naturally Occurring CD4+Foxp3+ Regulatory T Cells Are an Essential, IL-10-Independent Part of ...
Expression of Foxp3, TGF-β and IL-10 in American cutaneous leishmaniasis lesions. Regulatory T cells (Tregs) are a unique population of CD25+CD4+ T cells that regulate innate and adaptive immune responses and have the ability to control ... FMD Rodrigues,GTC Neto,JGPB Menezes,... - 《...
Cells stimulated with TGF-beta plus IL-6 were present in the spleen as well as the central nervous system, but they failed to upregulate the proinflammatory chemokines crucial for central nervous system inflammation. In addition, these cells produced IL-10, which has potent anti-inflammatory ...
目的探讨外周血CD4+CD25+Treg细胞数量和抑制性细胞因子TGF-βI,L-10含量变化在反复自然流产中的作用.方法采用ELISA法检测30例反复自然流产患者3,0例正常妊娠妇女和30例正常非孕妇女外周血抑制性细胞因子TGF-β和IL-10含量,三色流式细胞术检测上述研究对象外周血CD4+CD25+T细胞比例.结果反复自然流产组妇女外周血CD4+...
Malaria Journal 2014, 13:236 http://www.malariajournal.com/content/13/1/236 RESEARCH Open Access Association of candidate gene polymorphisms and TGF-beta/IL-10 levels with malaria in three regions of Cameroon: a case–control study Tobias O Apinjoh1, Judith K Anchang-Kimbi2, Clarisse Njua...