More recent work validates the potent immunomodulatory molecules transforming growth factor-beta (TGF-尾) and interleukin-10 (IL-10) as key targets for AD pharmacotherapy. Methods: We have crossed transgenic mouse models of AD with mice bearing genetically engineered immune/inflammatory genes targeting...
TGF β(tratorm growth factor beta,TGF β)作为公认的促纤维化因子在MFB分化过程中起着重要作用,以往研究发现IL 10可在体内减弱TGF β的促纤维化作用[2]。本实验通过IL 10干预TGF β作用后的成纤维细胞,观察IL 10是否可影响TGF β刺激成纤维细胞转分化作用。 1 材料和方法材料 细胞:①人胚肺成纤维细胞株:...
1、TGF-和IL-10在呼吸道合胞病毒毛细支气管炎患儿外周血中的含量及表达意义 摘要 目的 观察呼吸道合胞病毒毛细支气管炎患儿外周血中TGF-及IL-10的含量,并对其临床意义进行探讨。方法 选择2012年10月2013年10月间河北医科大学附属邢台市人民医院80例呼吸道合胞病毒毛细支气管炎检测为阳性的患儿为观察对象组,并以...
结论在体外IL 10对TGF β刺激成纤维细胞的增殖、胶原产生及α SMA表达有抑制作用,且呈剂量依赖性关键字:白细胞介素 10;成纤维细胞;平滑肌肌动蛋白【Abstract】ObjectiveToexploretheeffectsofIL 10onTGF βinducedtradifferentiationoffibroblasts,multiplicatioandgenerationofcollagen.MethodsHumanembryolungfibroblastswerepided...
BMC Infectious Diseases (2024) 24:652 https://doi.org/10.1186/s12879-024-09494-8 BMC Infectious Diseases RESEARCH Open Access Imbalanced IL10/TGF-β production by regulatory T-lymphocytes in patients with HTLV-1-associated myelopathy/ tropical spastic paraparesis Luana Leandro Gois1,2,3, ...
In contrast, in C3H/HeJ mice, a strain known to have stronger T-cell responses against hF.IX, IL-10 was specifically required for the suppression of CD8+ T-cell infiltration of the liver. Furthermore, TGF-β was critical for tipping the balance toward an regulatory immune response. TGF-...
Regulatory T cells and immune regulation of allergic diseases: roles of IL-10 and TGF-beta. Genes Immun. 2014; 15: 511-520. Ref.: https://goo.gl/rRUDoJPalomares O, Martin-Fontecha M, Lauener R, Traidl-Hoffmann C, Cavkaytar... O Palomares,M Martín-Fontecha,R Lauener,... - 《Gen...
The role of IL-10 and TGF-beta in the differentiation and effector function of T regulatory cells. Suppression by T regulatory (Tr) cells is essential for the induction of peripheral tolerance. Many types of CD4+ Tr cells have been described in a nu... MK Levings,R Bacchetta,U Schulz,...
Methods The effect of single nucleotide polymorphisms (SNPs) and plasma transforming growth factor beta (TGF-β) and interleukin 10 (IL-10) levels on malaria pathology was investigated in a case–control study of 1862 individuals from two major ethnic groups in three regions with intense perennial...
分类号:R78单位代码:10752 密级:公开学号:2010266 RAU患者外周血中 TGF-β1和IL-10的表达量及意义 ExpressionandsignificanceofTGF-β1andIL-10 inpatientswithrecurrentaphthousulcer 学位申请人: 王婷婷 指导教师: **教授 申请学位类别: 医学 专业领域名称:口腔医学 研究方向:口腔黏膜病学 所在学院: 口腔医学院 论...