More recent work validates the potent immunomodulatory molecules transforming growth factor-beta (TGF-尾) and interleukin-10 (IL-10) as key targets for AD pharmacotherapy. Methods: We have crossed transgenic mouse models of AD with mice bearing genetically engineered immune/inflammatory genes targeting...
摘要:目的探讨白介素10(interleukin10,IL10)对转化 生长因子β(tratormgrowthfactorbeta,TGFβ)刺激成纤维 细胞增殖、胶原分泌以及向肌成纤维细胞(myofibroblast,MFB)转化 的影响。方法培养人胚肺成纤维细胞,根据不同的处理方法分为五 组:A组加入TGFβ(5ng/ml),B组加TGFβ(5ng/ml)+IL10 ...
1、TGF-和IL-10在呼吸道合胞病毒毛细支气管炎患儿外周血中的含量及表达意义 摘要 目的 观察呼吸道合胞病毒毛细支气管炎患儿外周血中TGF-及IL-10的含量,并对其临床意义进行探讨。方法 选择2012年10月2013年10月间河北医科大学附属邢台市人民医院80例呼吸道合胞病毒毛细支气管炎检测为阳性的患儿为观察对象组,并以...
pathogens have developed strategies for subverting these responses and thereby establishing persistent or chronic infections. Furthermore, anti-pathogen effector immune responses must be tightly regulated to prevent collateral damage to host tissues. Regulatory...
分类号:R587.1密级:◎,∥■单位代码:10422学号:200712792囊办呈硕士学位论文ShandongUniversityMaster'sThesis论文题目:成人隐匿性自身免疫性糖尿病患者血清IL一10、TGF—p水平及其与胰岛p细胞功能的关系EXPRESSIONSOFIL一10ANDTGF・pANDTHEIRRELATIONSWITHISLETBETACELLFUNCTIONINADULTESWITHLATENTAUTOIMMUNEDIABETES作者专业导师...
目的探究转化生长因子β(TGF-β)和IL-10对胸膜间皮细胞(pleural mesothelial cells,PMCs)增殖、表面共刺激分子表达以及分泌一氧化氮(NO)功能的影响。 方法选择6～8周龄C57BL/6雌性野生型小鼠进行试验,通过胰酶消化法提取原代PMCs,加入TGF-β或IL-10刺激培养,运用流式细胞术检测PMCs增殖情况,细胞表面表达MHC-Ⅱ、CD...
Expression of Foxp3, TGF-β and IL-10 in American cutaneous leishmaniasis lesions. Regulatory T cells (Tregs) are a unique population of CD25+CD4+ T cells that regulate innate and adaptive immune responses and have the ability to control ... FMD Rodrigues,GTC Neto,JGPB Menezes,... - 《...
Malaria Journal 2014, 13:236 http://www.malariajournal.com/content/13/1/236 RESEARCH Open Access Association of candidate gene polymorphisms and TGF-beta/IL-10 levels with malaria in three regions of Cameroon: a case–control study Tobias O Apinjoh1, Judith K Anchang-Kimbi2, Clarisse Njua...
进而在局部释放新一轮的IL-6、IFN-γ、单核细胞趋化蛋白1和IP-10 （CXCL10）进入循环。
目的探讨外周血CD4+CD25+Treg细胞数量和抑制性细胞因子TGF-βI,L-10含量变化在反复自然流产中的作用.方法采用ELISA法检测30例反复自然流产患者3,0例正常妊娠妇女和30例正常非孕妇女外周血抑制性细胞因子TGF-β和IL-10含量,三色流式细胞术检测上述研究对象外周血CD4+CD25+T细胞比例.结果反复自然流产组妇女外周血CD4+...