A feedforward loop of NLRC5 (de)ubiquitination keeps IKK–NF-κB in check Many receptors signal via adaptors to the IKK-NF-κB axis, transducing extracellular cues to transcriptional regulation. In this issue, Meng et al. (2015. ... Y Hu - 《Journal of Cell Biology》 被引量: 1发表: ...
英文名称:IKKB phosphorylated Inhibitor Of Nuclear Factor kappa B Kinase beta Subunit I kappa B kinase beta IkBKB B kappa Kinase 2 Nuclear Factor NF Inhibitor IKKBIKKB phosphorylated Inhibitor Of Nuclear Factor,中文名称:核因子kappa B激酶β亚基磷酸化抑制
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ACT001 markedly inhibited NF-kappa B activation by directly binding IKK beta and inhibiting its phosphorylation. Overexpression of IKK beta markedly attenuated the changes in MnSOD and NOX1, indicating that ACT001 increased the levels of ROS by reducing the protein expression of p-IKK beta. Further...
NLK NF-κB TNFα IKKβ TAK1 1. Introduction Nuclear factor kappa-light-chain-enhancer of activated B cells (NF-κB) is a family of transcription factor complexes that regulate cell survival and proliferation. Dysregulation of NF-κB leads to chronic inflammatory diseases and development of cancer...