MRT67307 (IKKε/TBK1 Inhibitor II) inhibitsIKKεandTBK1with IC50 values of 160 nM and 19 nM at 0.1 mM ATP in vitro, but does not inhibit IKKα or IKKβ even at 10 μM. MRT67307 also is a highly potentULK1andULK2inhibitor with IC50s of 45 and 38 nM, respectively. MRT67307 can ...
(10)申请公布号 CN101541779A(43)申请公布日 2009.09.23 (21)申请号CN200780040236.6 (22)申请日2007.10.29 (71)申请人色品疗法有限公司 地址英国牛津郡 (72)发明人D·F·C·莫法特;S·J·戴维斯;M·H·查尔顿;S·C·赫斯特;S·T·奥尼恩斯;J·G·威廉姆斯 (74)专利代理机构上海专利商标事务所有限公司 ...
型号 CD-120H EP-1506L EP-1506S EP-1550S 用途范围 切割 作用原理 液压 颜色 绿 产地 日本 数量 160 电源 AC100V 材质 合金 质量 13.8kg 高 455 品牌 IKK DIAMOND 钻石牌 价格说明 价格:商品在爱采购的展示标价,具体的成交价格可能因商品参加活动等情况发生变化,也可能随着购买数量不同或所选规...
Additionally, OSS increased apoptosis, inflammatory changes, and oxidative stress in HUVECs, and these effects were reversed by down-regulation the expression of TLR2. We proved that OSS regulates the inflammatory response of endothelial cells through the TLR2-TAK1-IKK2 pathway. In the rats with...
Treatment-emergent adverse events in the study are tabulated in Table S1. We observed two cases of a pruritic, erythematous generalized rash more pronounced in the extremities in two of the six patients, in whom the rashes were biopsied and showed perivascular inflammation that could be consistent...
This study first demonstrated that NLRC3 deficiency promoted hypoxia-stimulated PASMCs proliferation, Human umbilical vein endothelial cells (HUVECs) apoptosis, migration and inflammation through IKK/NF-κB p65/HIF-1α pathway in vitro and in vivo, further promoted vascular remodeling and PH progression...
Mellan två katalytisk IKK subunitsna av komplexet IKK, IKK2 är primärt ansvarig14 för fosforyleringen av specifika rester av prototypiska IκBs (α, - β, & -γ) bundna till NF-κB och också en atypisk IκB protein, NF-κB1/p105, vilket är en föregångare av...
结果: 通过酶切鉴定和测序分析, 靶向IKKα的3个pGPU6/GFP/Neo-shRNA重组载体构建成功, Western blot结果显示pGPU6/GFP/Neo-shRNA3可有效抑制高糖诱导HUVECs中IKKα基因的表达, 抑制率为70.6%. 结论: 靶向IKKα基因的shRNA真核表达载体构建成功, 且能有效抑制HUVECs中IKKα基因的表达. 关键词: IKKα基因;...
Alzheimer’s disease (AD) is a common neurodegenerative disease that is accompanied by pronounced neuroinflammatory responses mainly characterized by marked microgliosis and astrogliosis. However, it remains open as to how different aspects of astrocytic and microglial activation affect disease progression....
This promotes the recognition of the PEST motif degron within IκBα by β-TrCP, which is part of the E3 ubiquitin ligase SCFβ-TrCP (S phase kinase-associated protein 1 (SKP1)-cullin 1-F-box protein containing β-transducing repeat-containing protein), and its K48-linked ubiquitylation, ...