Addressing this issue of HER2 test accuracy, the American Society of Clinical Oncologists (ASCO) and the College of American Pathologists (CAP) have recently released new guidelines for laboratory testing of HER2 status in breast cancer.51, 52 HER2 IHC scoring is reported as negative (0/1+),...
[5] Lin X, Zheng Q, Qi W, et al. Comparison of NGS and FISH Platforms to Test MET Amplification in Chinese Lung Cancer Patients: A Prospective Study. 2023 WCLC, P1.22-11. [6] Wu YL, Zhang L, Kim DW, Liu X, Lee DH, Yang JC, e...
总之,Idylla MSI测试已被证明是一种用于检测大肠癌患者微卫星状态的准确、快速的筛选检测方法,其无效结果较少。 原文题目:Clinical Performance of the Idylla MSI Testfor a Rapid Assessment of the DNA Microsatellite Status in Human ColorectalCancer 如需原...
而Her-2蛋白表达为(++)时,有必要进一步进行Her-2基因扩增的检测,Her-2蛋白表达为(+++)时可建议进行Her-2基因扩增的检测,来确定临床治疗是否应用Herceptin,为患者分子靶向治疗和预后评估提供实验依据。 [1]Ross J S,Gray G S.Targeted therapy for cancer:the HER-2/neu and Herceptin story[J].Clin Leadersh...
The presence of estrogen receptors (ERs), as detected by immunohistochemistry (IHC), is a weak prognostic marker of clinical outcome in breast cancer, but a strong predictive marker for response, for example, to tamoxifen-based therapy. As with all IHC markers, factors such as tissue fixation ...
Cells secrete a wide variety of proteins. Abnormal changes in a cell affect protein expression: some proteins cease expression, others overexpress, and some modify into a new protein. Classification of these changes is based on the area from which they originated. For each type of cancer within...
Comprehensive immunohistochemical analysis of Her-2/neu oncoprotein overexpression in breast cancer: HercepTest™ (Dako) for manual testing and Her-2/neu... (4B5) for immunohistochemical (IHC) determination of Her2 status in breast cancer: comparison with CB11, fluorescence in situ hybridization ...
Fluorescencein situhybridization (FISH) is increasingly being recognized as the most accurate and predictive test for HER2/neugene amplification and response to therapy in breast cancer. In the present study we investigated HER-2/neugene amplification by FISH in breast carcinoma tissue specimens and ...
%Objective To analyze and compare the fluorescence in situ hybridization(FISH) and immunohistochemical(IHC) for detecting HER-2 gene amplification and protein expression in breast cancer tissues .Methods 110 cases of breast cancer from Janu-ary 2008 to May 2012 receiving the modified radical ...
表1 乳腺癌HER2基因扩增和蛋白表达的结果Tab.1 Results of HER2 gene amplification and HER2 protein expression in breast cancer[n(η/%)]FISH IHC Negative Positive Total(—) 38 (95.00) 7(9.09) 45(58.44)(+) 2(2.59) 30 (38.96) 32(41.56)Total 40(51.95) 37(48.05) 77(100.00) 表2 IHC()和...