Alternatively, the Vγ2Vδ2 TCR could bind to a molecule that is recruited by the intracellular B30.2 domain upon HMBPP binding. To distinguish between these mechanisms, we mutagenized 32 residues on the surfaces of the IgV and IgC domains of BTN3A1 to alanine and tested the mutant ...
In antibodies, each Fab (fragment of antigen binding) is a heterodimeric association of two IgV domains (termed as VH and VL) followed by association of IgC domains of light and heavy chains. As shown in the Fig. 1a, the two IgV domains associate through their hydrophobic front face, where...
Here we describe soluble recombinant forms of B7-1 and B7-2 containing either both of the Ig-like domains or the individual IgV or IgC domains coupled to an Ig Fc tail. Soluble B7-1 and B7-2 bind to and , and effectively co-stimulate T lymphocytes resulting in their proliferation and ...
fusion proteingene expressionObjective To express human B7.2 extracellular domain with prokaryote expression system and to evaluate its biological activity in vitro. Methods PCR was used to amplify the extracellular region of human B7. 2which contained both the IgV and IgC domains. The recombinant ...
fusion proteingene expressionObjective: To express human B7.2 extracellular domain with prokaryote expression system and to evaluate its biological activity in vitro. Methods: PCR was used to amplify the extracellular region of human B7.2 which contained both the IgV and IgC domains. The recombinant ...
fusion proteingene expressionObjective To express human B7. 2 extracellular domain with prokaryote expression system and to evaluate its biological activity in vitro. Methods PCR was used to amplify the extracellular region of human B7. 2 which contained both the IgV and IgC ...