No NOTCH1 mutations were found in 11 IGHV4-39-used cases, including one case from subset #8. In 10 of 27 (37.0%) NOTCH1 mutated cases IgHV1-69 gene was used, while among wild type NOTCH1 patients IgHV1-69 was presented in 65/274 (23.7%) cases (p=0.12). Conclusion The ...
Usage of IGHV4-39 with Stereotypic B Cell Receptor Is An Independent Risk Factor of Chronic Lymphocytic Leukemia Transformation to RichterMarc C Levesque, MD, PhD and Nicholas Chiorazzi, MD. 7:00 AM. 777. A Different Ontogenesisfor CLL Cases Carrying Stereotyped Antonis Dagklis 1 * , Claudia...
No NOTCH1 mutations were found in 11 IGHV4-39-used cases, including one case from subset #8. In 10 of 27 (37.0%) NOTCH1 mutated cases IgHV1-69 gene was used, while among wild type NOTCH1 patients IgHV1-69 was presented in 65/274 (23.7%) cases (p=0.12). Conclusion The ...
中国患者的IGHV突变比例较高,IGHV3-7、IGHV3-74、IGHV4-39以及IGHV4-59片段的使用率较高,同型模式BCR的比例较低,但subset 8(8亚群)的比例较高。中国患者MYD88、KMT2D以及IGLL5基因的突变频率显著高于西方患者,而SF3B1基因的突变频率显著低于西方患者。 慢性淋巴细胞白血病的常见突变基因和途径。新诊断患者中...
1)IGVH未突变的CLL/SLL与RS相关,其中IGHV4-39/IGHD6-13/IGHJ5的转化风险最高,IGHV4-39更是独立的RS预测因子。2)端粒长度:端粒长度小于5000bp的5年RS风险显著高于大于5000bp(18.9% vs. 6.4%)。3)抗体表达:CD38,ZAP-70和CD49d的表达均与RS有关。4)细胞遗传学异常:del(11q22.3), del(17p13), del(...