Trametinib for the treatment of IGHV4-34, MAP2K1-mutant variant hairy cell leukemiaLeslie A. AndritsosDivision of Hematology, Department of Internal Medicine, The Ohio State University, Columbus, OH, USA;Nicole R. GrieselhuberDivision of Hematology, Department of Internal Medicine, The Ohio State...
Taken together, our results indicate that unlike other IGHV4-34 bearing IGs, CLL subset 4 mAbs have only limited reactivity to autoantigens, including linear NAL epitopes. Instead, this subset has acquired specific recognition of subtypes of an infectious agent, influenza A (H3 and H1), apparen...
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Over 30% of IGHV4-34 CLL cases can be assigned to different subsets with stereotyped BcR IG. The largest is subset #4 which represents ~1% of all CLL and ~10% of IGHV4-34 CLL and is considered a prototype for indolent disease. The BcR IG of a great majority (~85%) of IGHV4-34...
Trametinib for the treatment of IGHV4-34, MAP2K1-mutant variant hairy cell leukemiadoi:10.1080/10428194.2017.1365853Leslie A. AndritsosNicole R. GrieselhuberMirela AnghelinaKerry A. RogersSameek RoychowdhuryJulie W. ReeserCynthia D. Timmers
IgHV4-34Immunoglobulin heavy chain locus variable gene segment V4-34 (VH4.21) use in productive heavy chain (IgH) gene rearrangements has been described in a number of human reactive and autoimmune B cell responses, and has been shown to be frequently used in some series of cases of diffuse...
Trametinib for the treatment of IGHV4-34, MAP2K1-mutant variant hairy cell leukemiaSince its discovery in 1923 and further characterization in 1958, hairy cell leukemia (HCL) has undergone enormous advances in the understanding of the biology and treatment of the disease. Initially a uniformly ...
Temporal dynamics of clonal evolution in chronic lymphocytic leukemia with stereotyped IGHV4-34/IGKV2-30 antigen receptors: longi- tudinal immunogenetic evidence. Mol Med 2013;19:230-6.Sutton LA, Kostareli E, Stalika E, et al. Temporal dynamics of clonal evolution in chronic lymphocytic ...