The germline IGHV4-34 gene is inherently autoreactive and is often found in antibodies that bind to the surfaces of erythrocytes and B lymphocytes through the linear i blood group antigen, poly-N-acetyllactosamine (NAL). To test the reactivity of subset 4 monoclonal antibodies (mAbs) to auto...
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To understand the genetic mechanisms driving variant and IGHV4-34–expressing hairy-cell leukemias, we performed whole-exome sequencing of leukemia samples from ten affected individuals, including six with matched normal samples. We identified activating mutations in the MAP2K1 gene (encoding MEK1) ...
(2015) Transformation of IGHV4-34 + hairy cell leukaemia-variant with U2AF1 mutation into a clonally-related high grade B-cell lymphoma responding to immunochemotherapy. British Journal of Haematology , n/a-n/a /Magda Zanelli, Moira Ragazzi, Riccardo Valli, Simonetta Piattoni, Maria Isabel ...
IGHV4-34 geneMutational profileStereotyped receptorsChronic lymphocytic leukemia (CLL) is the most common mature B-cell neoplasm in the West. IGHV4-34 is one of the most frequently used genes in CLL patients, which usually display an indolent outcome. In this study, we explored the mutational ...
Trametinib for the treatment of IGHV4-34, MAP2K1-mutant variant hairy cell leukemiadoi:10.1080/10428194.2017.1365853Leslie A AndritsosNicole R GrieselhuberMirela AnghelinaKerry A RogersSameek RoychowdhuryJulie W ReeserCynthia D TimmersAharon G Freud...
Trametinib for the treatment of IGHV4-34, MAP2K1-mutant variant hairy cell leukemiaSince its discovery in 1923 and further characterization in 1958, hairy cell leukemia (HCL) has undergone enormous advances in the understanding of the biology and treatment of the disease. Initially a uniformly ...
High prevalence of MAP2K1 mutations in variant and IGHV4-34-expressing hairy-cell leukemias. Nat Genet 2014;46(1):8-10.Waterfall JJ, Arons E, Walker RL, Pineda M, Roth L, Killian JK, et al. High prevalence of MAP2K1 mutations in variant and IGHV4-34-expressing hairy-cell leukemias....