为了探究为什么IGHV1-69编码的L452靶向抗体会被广泛诱导,通过比较IGHV1-69与非IGHV1-69抗体与RBD的结合模式,发现IGHV1-69抗体都是利用HCDR2区域的胚系疏水氨基酸就能够与L452,F490,L492构成的疏水区相互作用。然而,其它非IGHV1-6...
为了探究为什么IGHV1-69编码的L452靶向抗体会被广泛诱导,通过比较IGHV1-69与非IGHV1-69抗体与RBD的结合模式,发现IGHV1-69抗体都是利用HCDR2区域的胚系疏水氨基酸就能够与L452,F490,L492构成的疏水区相互作用。然而,其它非IGHV1-69抗体则需要利用体细胞突变或VDJ重排后HCDR3中携带的疏水氨基酸与L452发生相互作...
为了探究为什么IGHV1-69编码的L452靶向抗体会被广泛诱导,通过比较IGHV1-69与非IGHV1-69抗体与RBD的结合模式,发现IGHV1-69抗体都是利用HCDR2区域的胚系疏水氨基酸就能够与L452,F490,L492构成的疏水区相互作用。然而,其它非IGHV1-69抗体则需要利用体细胞突变或VDJ重排后HCDR3中携带的疏水氨基酸与L452发生相互作...
2016. IGHV1-69 polymorphism modulates anti-influen- za antibody repertoires, correlates with IGHV utilization shifts and varies by ethnicity. Sci Rep 6: 20842.Avnir Y, Watson CT, Glanville J, Peterson EC, Tallarico AS, Bennett AS, Qin K, Fu Y, Huang CY, Beigel JH, Breden F, Zhu Q,...
近日,中国科学院广州生物医药与健康研究院(广州健康院)与广州医科大学附属第一医院、广州实验室等单位合作在EmergingMicrobes&Infections发表题为Shared IGHV1-69-encoded neutralizing antibodies contribute to the emergence of L452R substitution in SARS-CoV-2 variants的研究论文。
69-sBnAb clonal frequencies suggesting that the IgG switch memory B cell subset is subject to additional regulation (Supplementary Fig. 4e,f). Interestingly, all L/L individuals were found to have a mean CN = 2 and they also had the lowestIGHV1-69utilization among the three genotypic ...
目前我只知道IGHV是抗体重链胚系基因，不知道人的抗体重链有几种胚系基因?然后后面的1-69*01就完全不...
目前我只知道IGHV是抗体重链胚系基因，不知道人的抗体重链有几种胚系基因?然后后面的1-69*01就完全不...
These IGHV1-69 B-CLL antibodies preferentially used IGHD3 and IGHJ6 gene segments and had long heavy chain complementary determining region 3s (HCDR3s) (≥21 aa). IGHV1-69 B-CLL BCRs exhibited a phenylalanine at position 54 (F54) of the HCDR2 as do rare HIV-1 gp41 and influenza...
Figure 2. Analysis of G6 Idiotype by Using HV1-69-sBnAb Variants (A) The V-segment of the non-G6 reactive HV1-69-sBnAbs F10, CR6261, and A66 was replaced with the non-mutated IGHV1-69∗01 germline V-segment. Binding kinetics of the three variants (VH1-69/F10, A66, CR6261)...