Twelve 14q32 miRNAs appeared in the network including miR-543, miR-495-3p, miR-409-3p and miR-411-3p. Next, we evaluated the potential impact of the 14q32 miRNAs on the strongest components of the IGHV-associated expression signature using the same network approach for the top 200 DEG (...
Translocations leading to TCL1A overexpression (t(14;14)(q11;q32)) by putting TCL1A expression under the control of the IgHV promoter have been described as rare events in lymphomas. Besides, the TCL1A promoter has previously been shown to display hypomethylation in CLL cells, providing an ...